ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence

Chevalier, Mathieu F.; Trabanelli, Sara; Racle, Julien; Salomé, Bérengère; Cesson, Valérie; Gharbi, Dalila; Bohner, Perrine; Domingos-Pereira, Sonia; Dartiguenave, Florence; Fritschi, Anne-Sophie; Speiser, Daniel E.; Rentsch, Cyrill A.; Gfeller, David; Jichlinski, Patrice; Nardelli-Haefliger, Denise; Jandus, Camilla; Derré, Laurent

doi:10.1172/jci89717

Cited by 179 publications

(179 citation statements)

References 77 publications

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“…Indeed, some groups showed that all ILCs are CD161 1 and use this marker in their gating strategy (24,25), while others, including our group, do not add CD161 in the gating strategy (26)(27)(28). Indeed, some groups showed that all ILCs are CD161 1 and use this marker in their gating strategy (24,25), while others, including our group, do not add CD161 in the gating strategy (26)(27)(28).…”

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 65%

“…Another concern in the identification of human ILCs is represented by the use of the marker CD161. Indeed, some groups showed that all ILCs are CD161 1 and use this marker in their gating strategy (24,25), while others, including our group, do not add CD161 in the gating strategy (26)(27)(28). Since it was shown that CD161 is not present in all ILC subsets, being at least ILC1 and LTi CD161 1/2 (7,29), we propose not to include this marker in the gating strategy, thus avoiding to exclude from the analysis ILCs that are CD161 2 (Fig.…”

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 83%

“…However, only NKp46 is present in both humans and mice and is expressed regardless of the activation status of the cells (30). Therefore, even if several groups proposed to use NKp44 to define ILC3 NCR 1 cells (26,31), we and others suggested to use NKp46 (27,28,30). Once again, the frequencies of ILC3 NCR 1 and ILC3 NCR 2 change according to the choice of the NCR marker used for their identification (Fig.…”

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 98%

“…4). Therefore, even if several groups proposed to use NKp44 to define ILC3 NCR 1 cells (26,31), we and others suggested to use NKp46 (27,28,30). Here, the main concern is represented by the choice of the natural cytotoxicity receptor (NCR) used to discriminate between the two main subsets of ILC3, i.e., ILC3 NCR 1 and ILC3 NCR 2 .…”

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 99%

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Human innate lymphoid cells (ILCs): Toward a uniform immune‐phenotyping

Trabanelli

Gomez-Cadena

Salomé

et al. 2018

Cytometry Part B Clinical

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Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2, and ILC3, that can be specifically activated by different signals coming either indirectly from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions. The discovery and the study of these immune cells is now offering important opportunities for innovative therapies of allergic airway diseases, inflammatory disorders and might be crucial for the discovery of new targets for the therapy of cancer. It is therefore fundamental that the scientific community establishes harmonized guidelines to obtain a consensus in the identification and phenotypical and functional characterization of ILCs. © 2018 International Clinical Cytometry Society.

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Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 65%

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 83%

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 98%

Section: Cd161 and Nkp44: Should We Use Them?mentioning

confidence: 99%

See 2 more Smart Citations

Human innate lymphoid cells (ILCs): Toward a uniform immune‐phenotyping

Trabanelli

Gomez-Cadena

Salomé

et al. 2018

Cytometry Part B Clinical

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“…Lung ILC2s are known to play an important role in the development of allergic inflammation, and ILC2 numbers are elevated in the peripheral blood and sputum of asthma patients (Smith et al, 2016; Ying et al, 2016). ILC2s are involved in other lung diseases, including chronic obstructive pulmonary disease (Silver et al, 2016), fibrosis (Hams et al, 2014), and tumors (Trabanelli et al, 2017; Chevalier et al, 2017). It is important to elucidate the complexity of the ILC2 population and the functional properties of stimulated ILC2 subsets, as well as their development, so that proper subsets are targeted in therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets

Ghaedi

Shen

Orangi

et al. 2019

Journal of Experimental Medicine

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Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue repair. ILC2 development is dependent on the transcription factor retinoic acid receptor–related orphan receptor (RORα), which is also expressed in common ILC progenitors. To elucidate the developmental pathways of lung ILC2s, we generated RORα lineage tracer mice and performed single-cell RNA sequencing, flow cytometry, and functional analyses. In adult mouse lungs, we found an IL-18Rα+ST2− population different from conventional IL-18Rα−ST2+ ILC2s. The former was GATA-3intTcf7EGFP+Kit+, produced few cytokines, and differentiated into multiple ILC lineages in vivo and in vitro. In neonatal mouse lungs, three ILC populations were identified, namely an ILC progenitor population similar to that in adult lungs and two distinct effector ILC2 subsets that differentially produced type 2 cytokines and amphiregulin. Lung ILC progenitors might actively contribute to ILC-poiesis in neonatal and inflamed adult lungs. In addition, neonatal lung ILC2s include distinct proinflammatory and tissue-repairing subsets.

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Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder

Huang

et al. 2022

Advanced Science

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Innate lymphoid cells (ILCs) are crucial in orchestrating immunity and maintaining tissue homeostasis in various barrier tissues, but whether ILCs influence immune responses in the urinary tract remains poorly understood. Here, bladder‐resident ILCs are comprehensively explored and identified their unique phenotypic and developmental characteristics. Notably, bladder‐resident ILCs rapidly respond to uropathogenic Escherichia coli (UPEC) infection. It is found that ILC3 is necessary for early protection against UPEC infection in the bladder. Mechanistically, UPEC infection leads to interleukin (IL)‐1β production in the bladder via a MyD88‐dependent pathway, which promotes ILC3 activation. ILC3‐expressed IL‐17A further recruits neutrophils and controls UPEC infection in the bladder. Together, these results demonstrate a critical role for bladder ILCs in the host defense against UPEC infection.

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ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence

Cited by 179 publications

References 77 publications

Human innate lymphoid cells (ILCs): Toward a uniform immune‐phenotyping

Human innate lymphoid cells (ILCs): Toward a uniform immune‐phenotyping

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets

Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder

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