IL28B Polymorphisms as a Pretreatment Predictor of Response to HCV Treatment

Berger, Christoph T.; Kim, Arthur Y.

doi:10.1016/j.idc.2012.08.010

Cited by 12 publications

(5 citation statements)

References 104 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is a systematic review and meta‐analysis of studies associating host genetic polymorphisms with spontaneous or treatment‐induced HCV clearance between 1989 and 2013. While previous reviews were not systematic, focused on a specific marker, gene or group of genes, and were limited to a viral genotype or ethnic group, this review includes all genetic determinants of HCV clearance without limitations. To our knowledge, this is the most comprehensive review on this topic so far.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta‐analysis of HCV clearance

Gauthiez

Habfast-Robertson

Rüeger

et al. 2017

Liver International

View full text Add to dashboard Cite

While hepatitis C exemplifies the role of host genetics in infectious diseases outcomes, there is no comprehensive overview of polymorphisms influencing spontaneous and/or treatment‐induced hepatitis C virus clearance. We performed a systematic review and meta‐analysis of host polymorphisms associated with these phenotypes. Literature search was conducted using combinations of keywords in three databases. Studies were reviewed and relevant data systematically extracted for subsequent meta‐analyses. Polymorphisms from candidate gene studies were tested in two cohorts of HCV‐infected patients with available genomic data. The literature search yielded 8'294 citations, among which 262 studies were selected. In the meta‐analysis of 27 HLA studies, the most significant associations with spontaneous hepatitis C virus clearance included DQB1*02, DQB1*03, DRB1*04 and DRB1*11. In the meta‐analysis of 16 studies of KIR genes and their HLA‐ligands, KIR2DS3 was associated with both spontaneous and treatment‐induced clearance, and the HLA‐C2 ligand with failure to spontaneously clear the virus. In a pooled analysis of 105 candidate genes and two genome‐wide association studies, we observed associations of single nucleotide polymorphisms from nine genes (EIF2AK2, IFNAR2, ITPA, MBL2, MX1, OASL, SPP1, TGFB1, TNK2) with response to interferon‐based therapy. Meta‐analysis of 141 studies confirmed the association of IFNL3/4 polymorphisms with spontaneous and treatment‐induced hepatitis C virus clearance, even in previously underpowered groups, such as hepatitis C virus genotypes 2/3‐infected patients. This study may contribute to a better understanding of hepatitis C virus immunopathogenesis and highlights the complex role of host genetics in hepatitis C virus clearance.

show abstract

Section: Discussionmentioning

confidence: 99%

A systematic review and meta‐analysis of HCV clearance

Gauthiez

Habfast-Robertson

Rüeger

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

“…In a prospective international cohort study of injectable drug users with acute HCV infection, HCV RNA levels 12 months following infection were independently associated with male gender, IL28B CC rs12979860 genotype and HCV genotype 1 [24]. The importance of these results remains to be elucidated, as some studies have refuted the effect of HCV RNA loads on disease progression, but it is probable that high levels of HCV RNA may have an impact on immunological response and hepatic inflammation especially in advanced liver injury [25,26].…”

Section: Discussionmentioning

confidence: 99%

IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury

Jordovic¹,

Simonovic-Babic²,

Gasic

et al. 2019

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection. Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes. Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GTrs8099917 in 78.6% and GGrs12980275 in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes. Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.

show abstract

“…Knowledge on the molecular pathways of nutrients, according to the genetic identity of the patients, will enable the application of the most optimal treatment for each patient with AMD. Genetic profiling would likely contribute to our understanding of AMD and potentially provide more effective management of the disease, such as the case in HIV [89,90] and HCV [91,92] infection.…”

Section: Future Research Needsmentioning

confidence: 99%

Review of nutrient actions on age-related macular degeneration

Zampatti¹,

Ricci²,

Cusumano³

et al. 2014

Nutrition Research

View full text Add to dashboard Cite

The actions of nutrients and related compounds on age-related macular degeneration however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression.

show abstract

IL28B Polymorphisms as a Pretreatment Predictor of Response to HCV Treatment

Cited by 12 publications

References 104 publications

A systematic review and meta‐analysis of HCV clearance

A systematic review and meta‐analysis of HCV clearance

IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury

Review of nutrient actions on age-related macular degeneration

Contact Info

Product

Resources

About