2016
DOI: 10.1002/ijc.30134
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Abstract: Despite conventional treatment modalities, gallbladder cancer (GBC) remains a highly lethal malignancy. Prognostic biomarkers and effective adjuvant immunotherapy for GBC are not available. In the recent past, immunotherapeutic approaches targeting tumor associated inflammation have gained importance but the mediators of inflammatory circuit remain unexplored in GBC patients. In the current prospective study, we investigated the role of IL17 producing TCRcdand regulatory T cells (Tregs) in pathogenesis of GBC.… Show more

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Cited by 121 publications
(116 citation statements)
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“…[39] Furthermore, the accumulation of γδT cells, which shows an autoimmune response to infections or cancers, is reportedly governed by CXCL9/CXCR3 axis-dependent mechanisms. [40] Interestingly, although CXCL4 induces apoptotic signals through CXCL4/CXCR3B axis,[32] Korniejewska et al showed that CXCL4 could not elicit T cell migration in spite of intracellular calcium mobilization as well as phosphorylation of Akt and ERK. It means CXCL4 may have other roles in T cell function.…”
Section: Cxcl9 Cxcl10 Cxcl11/cxcr3 Axis For Immune Responsementioning
confidence: 99%
“…[39] Furthermore, the accumulation of γδT cells, which shows an autoimmune response to infections or cancers, is reportedly governed by CXCL9/CXCR3 axis-dependent mechanisms. [40] Interestingly, although CXCL4 induces apoptotic signals through CXCL4/CXCR3B axis,[32] Korniejewska et al showed that CXCL4 could not elicit T cell migration in spite of intracellular calcium mobilization as well as phosphorylation of Akt and ERK. It means CXCL4 may have other roles in T cell function.…”
Section: Cxcl9 Cxcl10 Cxcl11/cxcr3 Axis For Immune Responsementioning
confidence: 99%
“…[14][15][16] Nevertheless, human thymic cd T cells exhibit de novo expression of type 1 transcription factors T-bet and eomesodermin, reflecting their capacity to rapidly differentiate into cytotoxic effectors producing IFN-c in response to cytokines IL-2 and IL-15. 24,37,39,40 A recent extensive study sequencing bulk transcriptomes of 18 000 human tumors revealed that, among all leucocytes present in the tumors, cd T cells were most strongly associated with good prognosis. cd T cells also display an NK-like phenotype in their expression of NCRs (NKp30, NKp44 and NKp46), particularly following activation.…”
Section: Introductionmentioning
confidence: 99%
“…cd T cells also display an NK-like phenotype in their expression of NCRs (NKp30, NKp44 and NKp46), particularly following activation. 40 There have also been reports of cd T cells having a potential tumor-promoting role in various human malignancies, 37,40,42 likely attributable to their functional plasticity in various inflammatory microenvironments, although determination of a direct immunosuppressive role for human cd T cells in situ is difficult. * denotes expression on some clones only.…”
Section: Introductionmentioning
confidence: 99%
“…Likewise, the expression of CXCR3 by lymphocytes can mediate its migration to GBC tumor beds [27]. These data suggest that the induction of these chemokine receptors in T cells by therapeutic DCs would be beneficial for the DC-mediated anti-tumor responses in vaccinated patients.…”
Section: Discussionmentioning
confidence: 99%