IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes

Dumoutier, Laure; Roost, Emiel Van; Ameye, Geneviève; Michaux, Lucienne; Renauld, Jean Christophe

doi:10.1038/sj.gene.6363716

Cited by 186 publications

(114 citation statements)

References 14 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…Distinct regulation of IL-17 and IL-22. IL-22 is a member of the IL-10 family, and its gene is located on chromosome 12q15 between the IFN␥ and IL-26 loci (40,41). Recently, IL-22 has been reported to be produced by murine Th17 cells in vitro and in vivo (12,42).…”

Section: Il-17 Regulation In Human T Cells 2941mentioning

confidence: 99%

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Chen¹,

Tato²,

Muul³

et al. 2007

Arthritis & Rheumatism

317

281

View full text Add to dashboard Cite

Section: Il-17 Regulation In Human T Cells 2941mentioning

confidence: 99%

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Chen¹,

Tato²,

Muul³

et al. 2007

Arthritis & Rheumatism

317

281

View full text Add to dashboard Cite

“…IL-10 has also been implicated in the generation and maintenance of regulatory T cells, further emphasizing its important role in immune regulation [12,13]. In recent years, five novel cytokines that are structurally related to IL-10 have been identified [14][15][16][17][18]. These cytokines constitute the 'IL-10 family', consisting of IL-10 itself, IL-19, IL-20, IL-22, IL-24 and IL-26 [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

et al. 2005

View full text Add to dashboard Cite

IL‐19 is a novel, recently identified member of the IL‐10 family of cytokines. We identified IL‐10 as a cytokine that was strongly induced in IL‐19‐stimulated PBMC. IL‐19‐induced IL‐10 secretion was dose‐dependent and could be detected in culture supernatants after 3 h of stimulation. Furthermore, quantitative RT‐PCR analysis demonstrated that IL‐19 stimulation increased the level of IL‐10 mRNA present within cells, suggesting that IL‐19 is a transcriptional activator of IL‐10. IL‐19 was also able to induce its own expression, with IL‐10 potently down‐regulating this IL‐19 ‘auto‐induction’. LPS induction of IL‐19 expression was also regulated by IL‐10, demonstrating that IL‐10 is likely an important regulator of human IL‐19 induction. Maturation of dendritic cells from human PBMC in the presence of IL‐19 resulted in an increase in IL‐10 levels within these cells, whereas IL‐12 was not affected. These results advance our understanding of the function of this novel cytokine and its regulation within the human immune system, in addition to providing a new insight into the control of the important immunoregulatory cytokine, IL‐10.

show abstract

“…I nterleukin 10-related related T cell-derived inducible factor (IL-TIF) is a cytokine structurally related to IL-10 and originally identified as a gene induced by IL-9 in murine T lymphocytes (1,2). This cytokine, for which the name IL-22 was recently proposed (3), is expressed in vitro by T helper cells upon activation by IL-9, anti-CD3 Abs, or Con A and by IL-9-stimulated mast cells.…”

mentioning

confidence: 99%

Cloning and Characterization of IL-22 Binding Protein, a Natural Antagonist of IL-10-Related T Cell-Derived Inducible Factor/IL-22

Dumoutier

Lejeune

Colau

et al. 2001

The Journal of Immunology

234

211

View full text Add to dashboard Cite

The class II cytokine receptor family includes the receptors for IFN-αβ, IFN-γ, IL-10, and IL-10-related T cell-derived inducible factor/IL-22. By screening genomic DNA databases, we identified a gene encoding a protein of 231 aa, showing 33 and 34% amino acid identity with the extracellular domains of the IL-22 receptor and of the IL-20R/cytokine receptor family 2-8, respectively, but lacking the transmembrane and cytoplasmic domains. A lower but significant sequence identity was found with other members of this family such as the IL-10R (29%), cytokine receptor family 2-4/IL-10Rβ (30%), tissue factor (26%), and the four IFN receptor chains (23–25%). This gene is located on chromosome 6q24, at 35 kb from the IFNGR1 gene, and is expressed in various tissues with maximal expression in breast, lungs, and colon. The recombinant protein was found to bind IL-10-related T cell-derived inducible factor/IL-22, and to inhibit the activity of this cytokine on hepatocytes and intestinal epithelial cells. We propose to name this natural cytokine antagonist IL-22BP for IL-22 binding protein.

show abstract

IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes

Cited by 186 publications

References 14 publications

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Distinct regulation of interleukin‐17 in human T helper lymphocytes

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

Cloning and Characterization of IL-22 Binding Protein, a Natural Antagonist of IL-10-Related T Cell-Derived Inducible Factor/IL-22

Contact Info

Product

Resources

About