IL‐6 and IL‐1β expression is increased in autologous serum skin test of patients with chronic spontaneous urticaria

Montjoye, Laurence de; Choteau, Mathilde; Herman, Anne; Hendrickx, Emilie; Chéou, Paméla; Baeck, Marie; Dumoutier, Laure

doi:10.1111/all.13928

Cited by 10 publications

(9 citation statements)

References 25 publications

(40 reference statements)

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“…38,39 Similarly, IL-1β and IL-6 are proinflammatory cytokines released by macrophages and dendritic cells and their upregulation have been associated with allergic reactions such as asthma and urticaria. 40,41 Furthermore, IL-5 and IL-13 are important CD4 T-cells and ILC2-derived cytokines that are involved in eosinophilia, mucus production, and airway hyperreactivity, and they have been suggested as biomarkers and therapeutic targets for type-2 inflammationrelated disorders such as allergic asthma. [42][43][44][45] An interesting observation is that mice treated with the microbial powder had a lower abundance of phylum Actinobacteria in the gut after the whole exposure period.…”

Section: Discussionmentioning

confidence: 99%

Effect of inactivated nature‐derived microbial composition on mouse immune system

González-Rodríguez

Nurminen

Kummola

et al. 2021

Immunity Inflam & Disease

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Introduction:The hygiene hypothesis suggests that decrease in early life infections due to increased societal-level hygiene standards subjects one to allergic and autoimmune diseases. In this report, we have studied the effect of sterilized forest soil and plant-based material on mouse immune system and gut microbiome.Methods: Inbred C57Bl/6 mice maintained in normal sterile environment were subjected to autoclaved forest soil-derived powder in their bedding for 1 h a day for 3 weeks. Immune response was measured by immune cell flow cytometry, serum cytokine enzyme-linked immunoassay (ELISA) and quantitative polymerase chain reaction (qPCR) analysis. Furthermore, the mouse gut microbiome was analyzed by sequencing. Results: When compared to control mice, mice treated with soil-derived powder had decreased level of pro-inflammatory cytokines namely interleukin (IL)−17F and IL-21 in the serum. Furthermore, splenocytes from mice treated with soil-derived powder expressed less IL-1b, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF) upon cell activation. Gut microbiome appeared to be stabilized by the treatment.Conclusions: These results provide insights on the effect of biodiversity on murine immune system in sterile environment. Subjecting mice to soil-based plant and microbe structures appears to elicit immune response that could be beneficial, for example, in type 2 inflammation-related diseases, that is, allergic diseases.

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Section: Discussionmentioning

confidence: 99%

Effect of inactivated nature‐derived microbial composition on mouse immune system

González-Rodríguez

Nurminen

Kummola

et al. 2021

Immunity Inflam & Disease

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“…IL-6 can activate Janus tyrosine kinase (JAK)/STAT3, Ras/MAPK, PI3K-PKB/Akt, and other signaling pathways, thereby participating in the pathogenesis of certain diseases [39]. Studies have shown that IL-6 was also elevated in the spontaneous urticaria wheals compared with unaffected skin [40]. And in CU, the serum level of IL-6 is significantly related to the UAS and the quality of life score.…”

Section: Il-6/janus Tyrosine Kinase/stat Pathwaymentioning

confidence: 99%

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

Zhang

et al. 2021

Int Arch Allergy Immunol

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Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis edema, erythema, pruritus, or burning sensation). According to whether the natural course exceeds 6 weeks, urticaria can be divided into acute and chronic urticaria (CU). At present, the evaluation of CU activity mainly depends on the Urticaria Activity Score (UAS), but the evaluation indicators are relatively single, and we need more reliable experimental data for evaluation. We typically summarize advanced biomarkers and several related pathogenic pathways discovered in recent years on urticaria, including the cell adhesion/chemotaxis pathway, interleukin (IL)-6/Janus tyrosine kinase/STAT pathway, IL-17/IL-23 pathway, basophil- and mast cell-related pathway, coagulation/fibrinolysis-related pathways, single-nucleotide polymorphism, and some other pathways. This review aims to find appropriate biomarkers so that we can evaluate disease activity, discover novel therapeutic targets, and predict the patients’ response more accurately to therapeutic agents.

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“…IL6, a cytokine that plays an important role in in ammation and immune response, is involved in the development of various autoimmune and chronic in ammatory diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus, Multiple sclerosis, adult Still's disease and psoriasis [29][30][31]. More and more evidences-the expression of IL6 in serum and skin lesion tissue of CSU patients signi cantly increased and its expression level can be signi cantly reduced after the symptoms are relieved, suggest that IL6 is also involved in the occurrence and development of CSU [32,33]. IL6 mainly works in immune and in ammatory responses through two different pathways: one is that after binding to the low-a nity cell membrane IL6 receptor (IL6R), it interacts with the signal transduction component glycoprotein 130 ( gp130) to form a high-a nity complex that initiates intracellular signaling (classical receptor signaling pathway); the other is that IL6 binds to soluble IL6 receptor (sIL6R) and then forms a complex with gp130, resulting in a signal Transduction (trans signaling pathway) [34].…”

Section: Discussionmentioning

confidence: 99%

Integrated bioinformatics approach to understand immune-related key genes and pathways in chronic spontaneous urticaria

Su¹,

Huang²,

Zhao³

et al. 2020

Preprint

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Background Chronic spontaneous urticaria (CSU) refers to recurrent urticaria that lasts for more than 6 weeks in the absence of an identifiable trigger. Due to its recurrent wheal and severe itching, CSU seriously affects patients' life quality. There is currently no radical cure for it and its vague pathogenesis limits the development of targeted therapy. With the goal of revealing the underlying mechanism, two data sets with accession numbers GSE57178 and GSE72540 were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the differentially expressed genes (DEGs) of CSU skin lesion samples and healthy controls, four kinds of analyses were performed, namely functional annotation, protein-protein interaction (PPI) network and module construction, co-expression and drug-gene interaction prediction analysis, and immune and stromal cells deconvolution analyses. Results 92 up-regulated genes and 7 down-regulated genes were selected for subsequent analyses. Through the enrichment analysis of the core modules, three signal pathways were found to be closely related to the occurrence and development of CSU, including TNF signaling pathway, NF-κB signaling pathway and Jak-STAT signaling pathway. Referring to protein-protein interaction (PPI) network analysis and GeneCards database, we identified four key genes, IL6, TLR4, ICAM1, and PTGS2. In addition, according to the results of immune infiltration analysis, CSU tissue generally contained a higher proportion of dendritic cells, Th2 cells, mast cells, megakaryocyte-erythroid progenitor, preadipocytes, and macrophages M1. Conclusions To conclude, the key genes and pathways identified from CSU lesions and normal controls along with the immune infiltration profile may provide new insights into the development of CSU.

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IL‐6 and IL‐1β expression is increased in autologous serum skin test of patients with chronic spontaneous urticaria

Cited by 10 publications

References 25 publications

Effect of inactivated nature‐derived microbial composition on mouse immune system

Effect of inactivated nature‐derived microbial composition on mouse immune system

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

Integrated bioinformatics approach to understand immune-related key genes and pathways in chronic spontaneous urticaria

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