IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases

Zhu, Zhendong; Zhang, Yunmei; Ji-yun, YE; Wang, Xuechang; Fu, Xuemei; Wen, Jin; Wu, Xinran; Xia, Zhonghua

doi:10.1016/j.humimm.2018.10.009

Cited by 26 publications

(24 citation statements)

References 26 publications

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“…A and B). In line with previous studies, we found that IL‐35 promoted STAT3 phosphorylation (Fig. C), which was abolished by depletion of IL‐35 (Fig.…”

Section: Resultssupporting

confidence: 93%

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Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in mice

Xue

et al. 2019

Int Forum Allergy Rhinol

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Background:The therapeutic efficacy of allergic rhinitis (AR) needs to be improved. Probiotics have immunoregulatory functions. In this study we evaluated the effects of protein extracts of probiotics in the amelioration of AR.Methods: Extracts of Bifidobacterium infantis (EBI) were prepared by lysing the live probiotics. AR mice were developed to be used to evaluate the therapeutic efficacy of EBI. Results:The results show that EBI induced interleukin (IL)-10-producing dendritic cells (DCs) via increasing IL-35 and signal transducer and activator of transcription 3 (STAT3) phosphorylation. IL-10-expressing DCs induced IL-10-producing B cells (B10 cells), with the la er showing immunosuppressive functions. A er challenge with specific antigens, AR mice showed sneezing, nasal itch, and increases in serum-specific immunoglobulin E (IgE) and mouse mast cell protease-1; higher levels of T helper 2 (Th2) cytokines (IL-4, 67.17 ± 10.66; IL-5, 62.83 ± 9.70; IL-13, 51.00 ± 6.69, before treatment) in nasal mucosal protein extracts, which were significantly suppressed (IL-4, 27.00 ± 6.66; 23.86 ± 4.53;25.67 ± 4.93, a er treatment (p < 0.001) by administration with EBI nasal drops.Conclusion: EBI can suppress AR via inducing B10 cells. Thus, a er carrying out required preclinical experiments and tests, EBI has the translational potential to be used in the treatment of AR and other allergic diseases. C 2019 ARS-AAOA, LLC. How to Cite this Article:Xue J-M, Ma F, An Y-F, et al. Probiotic extracts ameliorate nasal allergy by inducing interleukin-35-producing dendritic cells in mice. Int Forum Allergy Rhinol. 2019;9: 1289-1296.A llergy (AR) is an adverse response to food antigens by the immune system in the airway mucosa. The under-

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“…A and B). In line with previous studies, we found that IL‐35 promoted STAT3 phosphorylation (Fig. C), which was abolished by depletion of IL‐35 (Fig.…”

Section: Resultssupporting

confidence: 93%

“…It was reported in a previous study that IL‐35 facilitates STAT3 phosphorylation to promote IL‐10 expression in B cells . We also found that EBI increased IL‐35 in DCs and then promoted the phosphorylation of STAT3 in DCs.…”

Section: Discussionsupporting

confidence: 81%

Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in mice

Xue

et al. 2019

Int Forum Allergy Rhinol

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“…Numerous studies have confirmed that IL-27 expression is increased in plasma and plaques in the coronary and carotid arteries of coronary artery disease patients (Kempe et al, 2009;Jin et al, 2012;Lin et al, 2012;A Shahi et al, 2015;Gregersen et al, 2017). Abundant evidence identifies that IL-35 expression is significantly reduced in patients with coronary artery disease; plasma IL-35 levels are gradually reduced in SAP, UAP, and AMI patients, and decreased plasma IL-35 levels are inversely correlated with the left ventricular ejection fraction (LVEF) in coronary artery diseases (Lin et al, 2012;Rasa et al, 2018;Zhu et al, 2018).…”

Section: Clinical Datamentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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“…As a cytokine constitutively expressed by Tregs, it has been proposed to induce IL-10-producing regulatory B cell, 119 in a STAT-3-dependent manner. 120 Several months later, Claudia Mauri's group described for the first time the existence of regulatory B cells in humans. 2 In the same year, three independent studies identified an association between B cells and transplantation tolerance in kidney transplant recipients.…”

Section: Other Mechanisms Of Breg Functionmentioning

confidence: 99%

“…in a STAT-3-dependent manner 120. It can also be produced by B cells, to promote the expansion of both IL-10-and IL-35-expressing Bregs, both of which have been shown to suppress IL-17-producing T cells 110.…”

mentioning

confidence: 99%

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Alhabbab

Nova‐Lamperti

Aravena

et al. 2019

Immunological Reviews

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The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of “inhibitory” antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody‐independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.

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IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases

Cited by 26 publications

References 26 publications

Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in mice

Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in mice

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

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