IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

Peshkova, Iuliia O.; Aghayev, Turan; Fatkhullina, Aliia R.; Makhov, Petr; Titerina, Elizaveta K.; Eguchi, Satoru; Tan, Yin Fei; Kossenkov, Andrew V.; Хорева, М. В.; Gankovskaya, L. V.; Sykes, Stephen M.; Koltsova, Ekaterina K.

doi:10.1038/s41467-019-13017-4

Cited by 38 publications

(34 citation statements)

References 71 publications

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“…Only one recent animal study reported that deletion of IL-27R reduced the formation of abdominal aortic aneurysm in ApoE deficiency mice, the mechanisms may be associated with a blunted accumulation of myeloid cells in the aorta (Peshkova et al, 2019).…”

Section: Interleukin-12 Family Members and Aortic Aneurysms And Aortimentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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Section: Interleukin-12 Family Members and Aortic Aneurysms And Aortimentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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“…In sepsis patients, IL-27 promoted the inflammatory response and aggravated liver damage [38]. IL-27Rα deficiency could protect abdominal aortic aneurysm development through limiting accumulation of myeloid cells and Ang II-induced hematopoietic stem cell expedition [39]. These studies indicated that the IL-27Rα signal plays a pro-inflammation role.…”

Section: Discussionmentioning

confidence: 95%

IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection

Zhao

Shi

et al. 2020

IJMS

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Non-invasively monitoring allogeneic graft rejection with a specific marker is of great importance for prognosis of patients. Recently, data revealed that IL-27Rα was up-regulated in alloreactive CD4+ T cells and participated in inflammatory diseases. Here, we evaluated whether IL-27Rα could be used in monitoring allogeneic graft rejection both in vitro and in vivo. Allogeneic (C57BL/6 donor to BALB/c recipient) and syngeneic (BALB/c both as donor and recipient) skin grafted mouse models were established. The expression of IL-27Rα in grafts was detected. The radio-probe, 125I-anti-IL-27Rα mAb, was prepared. Dynamic whole-body phosphor-autoradiography, ex vivo biodistribution and immunofluorescence staining were performed. The results showed that the highest expression of IL-27Rα was detected in allogeneic grafts on day 10 post transplantation (top period of allorejection). 125I-anti-IL-27Rα mAb was successfully prepared with higher specificity and affinity. Whole-body phosphor-autoradiography showed higher radioactivity accumulation in allogeneic grafts than syngeneic grafts on day 10. The uptake of 125I-anti-IL-27Rα mAb in allogeneic grafts could be almost totally blocked by pre-injection with excess unlabeled anti-IL-27Rα mAb. Interestingly, we found that 125I-anti-IL-27Rα mAb accumulated in allogeneic grafts, along with weaker inflammation earlier on day 6. The high uptake of 125I-anti-IL-27Rα mAb was correlated with the higher infiltrated IL-27Rα positive cells (CD3+/CD68+) in allogeneic grafts. In conclusion, IL-27Rα may be a novel molecular imaging marker to predict allorejection.

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“…It has been shown that the level of IL27 in blood is possibly an important marker for assessing the rate of HSC aging [ 232 ]. An increase in the IL27 concentration also leads to stress myelopoiesis resulting in the development of abdominal aortic lesions [ 233 ]. IL27 levels have been shown to be minimal in early childhood, but the peak of cytokine production by dendritic cells occurs during adulthood and possibly at old age [ 234 ].…”

Section: Age-associated Inflammatory Factorsmentioning

confidence: 99%

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

et al. 2020

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According to the World Health Organization, the population of over 60 will double in the next 30 years in the developed countries, which will enforce a further raise of the retirement age and increase the burden on the healthcare system. Therefore, there is an acute issue of maintaining health and prolonging active working longevity, as well as implementation of early monitoring and prevention of premature aging and age-related disorders to avoid early disability. Traditional indicators of biological age are not always informative and often require extensive and expensive analysis. The study of blood factors is a simple and easily accessible way to assess individual health and supplement the traditional indicators of a person’s biological age with new objective criteria. With age, the processes of growth and development, tissue regeneration and repair decline; they are gradually replaced by enhanced catabolism, inflammatory cell activity, and insulin resistance. The number of senescent cells supporting the inflammatory loop rises; cellular clearance by autophagy and mitophagy slows down, resulting in mitochondrial and cellular damage and dysfunction. Monitoring of circulated blood factors not only reflects these processes, but also allows suggesting medical intervention to prevent or decelerate the development of age-related diseases. We review the age-related blood factors discussed in recent publications, as well as approaches to slowing aging for healthy and active longevity.

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IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

Cited by 38 publications

References 71 publications

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

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