IL-26 in asthma and COPD

Cardenas, Eduardo I.; Fru, Karlhans; Konradsen, Jon R; Bao, Ande; Lindén, Anders

doi:10.1080/17476348.2022.2045197

Cited by 9 publications

(11 citation statements)

References 66 publications

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“…From an immunological point-of-view, it is feasible that IL-26 is involved in acute COVID-19, given its dual role as an antiviral and neutrophil-mobilizing mediator of host defense. It is known that the expression of IL-26 occurs constitutively in several immune and structural cells, and that it is enhanced upon TLR stimulation ( 31 ). Moreover, the genetic material of SARS-CoV-2 is recognized by TLR3 ( 21 ), TLR7 ( 21 , 22 ), and TLR8 ( 22 ), critical receptors that are known to mediate the production of IL-26 in primary human bronchial epithelial cells ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between IL-26 and the neutrophil-mobilizing cytokines IL-6, IL-8, and TNFα that we found in the current study is likely to be multifaceted. On the one hand, it is known that similar stimuli (e.g., TLR4 stimulation) can trigger the concomitant production of IL-6, IL-8, IL-26, and TNFα ( 31 , 32 ). On the other hand, IL-26 alone or bound to NETs can induce the production of IL-8 and TNFα in unsorted BAL cells ( 10 ) and IL-6 in PBMCs ( 18 ), while inhibiting the production of the same cytokines in primary bronchial epithelial cells ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

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Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

et al. 2022

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Interleukin-26 (IL-26) is released by several immune and structural cells following stimulation of toll-like receptors (TLRs), whereupon it can directly inhibit viral replication and enhance neutrophil chemotaxis. Given these unique properties, IL-26 has emerged as an intriguing mediator of host defense in the lungs. However, the role of IL-26 in COVID-19 has not been thoroughly investigated. Here, we characterized the involvement of IL-26 in the hyperinflammation and tissue damage that occurs in patients with acute COVID-19. We found that IL-26 is markedly increased in blood samples from these patients, and that the concentration of IL-26 correlates with those of the neutrophil-mobilizing cytokines IL-8 and TNFα, respectively. Moreover, the increase in blood IL-26 correlates with enhanced surface expression of the “don’t eat me” signal CD47 on blood neutrophils isolated from patients with acute COVID-19. Finally, we found that the blood concentration of IL-26 correlates with that of increased lactate dehydrogenase, an established marker of tissue damage, and decreased mean corpuscular hemoglobin (MCH), a previously verified hematological aberration in COVID-19, both of which are associated with severe disease. Thus, our findings indicate that increased systemic IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19, thereby forwarding the kinocidin IL-26 as a potential target for diagnosis, monitoring, and therapy in this deadly disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

et al. 2022

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“…121 Its overexpression is also evident in the case of chronic bronchitis and asthma. 122 The plethora of potentials with a few of them mentioned above allows it to qualify as a highly potent candidate to be used as a biomarker for various diseases.…”

Section: Ils: Types and Expressionmentioning

confidence: 99%

Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection

et al. 2022

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Interleukins (ILs) are a major subclass of cytokines which act as molecular messengers playing a role in immune system responses via cascade of signalling pathways. Belonging to the cytokine family, ILs play a crucial role in the theronostics of various diseases. Their abnormal expression leads to development of various diseases such as cancer, neurodegenerative diseases, allergies, asthma, autoimmune diseases, and other physiological abnormalities. This paves the way for exploring ILs to develop sensitive and efficient biosensors, and promoting them for clinical testing in a wide array of diseases. Furthermore, detecting the level of ILs is very important for their early diagnosis and their progression within the body, and simultaneously for possible immunotherapeutic approaches. To achieve this goal, multidisciplinary scientific approaches involving immunology, electrochemistry, nanotechnology, photometry, etc. are already being put into action. Advancements in nanoscience and nanotechnology are aiding in the development of highly sensitive biosensors for ILs detection. This review focuses on a detailed description of all presently discovered ILs and their roles in various diseases. Simultaneously, it also discusses the various electrochemical biosensors that can be employed for the detection of ILs in bodily fluids. Moreover, the role of nanomaterials in electrochemical biosensing are also discussed here.

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“…Likewise, extracellular IL-26 levels in long-term smokers were further increased in the induced sputum in patients with exacerbations of COPD compared to steady-state patients, in BAL samples from patients with chronic bronchitis, and in the induced sputum and BW samples in subjects with chronic colonization by pathogenic bacteria [ 40 ]. Interestingly, a gradual and statistically significant increase in IL-26 levels in induced sputum was detected in the period prior to an exacerbation, occurring 17 (14–23) days before the clinical event, indicating a potential role of IL-26 as a biomarker of upcoming exacerbations [ 7 , 40 ].…”

Section: The Role Of Il-26 In Copd and Chronic Bronchitismentioning

confidence: 99%

“…The IL-10 superfamily, which belongs to the type II group of cytokines, has nine members, namely, IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29, and, except for IL-10, which applies to immunomodulatory functions, all other members are pro-inflammatory cytokines that interfere with inflammation [ 5 ]. Intriguingly, the IL-10-related cytokine IL-26 is largely expressed in human airways [ 6 ], and alterations in its expression are associated with decreased lung function and reductions in markers of neutrophilic inflammation in Chronic Obstructive Pulmonary Disease (COPD) [ 7 ]. In this review, we aim to discuss the current role of IL-26 in the lung, with an emphasis on systemic inflammation in patients suffering from COPD and chronic bronchitis.…”

Section: Introductionmentioning

confidence: 99%

IL-26 in the Lung and Its Role in COPD Inflammation

Bartziokas

Fouka

Loukides

et al. 2022

JPM

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IL-26 is a cytokine expressed by infiltrating pro-inflammatory IL-17-producing T cells in the tissues of patients with chronic lung inflammation. IL-26 induces the chemotactic response of human neutrophils to bacteria and other inflammatory stimuli. In recent years, the innovative properties of IL-26 have been described. Studies have shown that, as DNA is released from damaged cells, it binds to IL-26, which plays the role of a carrier molecule for extracellular DNA, further contributing to its binding to the site of inflammation. This mechanism of action indicates that IL-26 may serve both as a driver as well as a stimulus of the inflammatory process, leading to the installation of a noxious amplification loop and, eventually, persistent inflammation. IL-26 also demonstrates direct antimicrobial effects derived from its capability to create pores and disrupt bacterial membranes, as indicated by the presence of membrane blebs on the surface of the bacteria and cytosolic leakage pores in bacterial walls, produced in response to microbial stimuli in human airways by several different immune and structural cells. Surprisingly, while this particular cytokine induces the gathering of neutrophils in areas of infection, it also exhibits inhibitory and pro-inflammatory effects on airway epithelial and immune cells. These remarkable effects underline the necessity of a better understating of its biological behavior and its role in the pathophysiology and disease burden in several smoking-related airway inflammatory disorders, such as Chronic Obstructive Pulmonary Disease (COPD) and chronic bronchitis. In this review, we aim to discuss the current role of IL-26 in the lung, with an emphasis on systemic inflammation in patients suffering from COPD and chronic bronchitis.

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IL-26 in asthma and COPD

Cited by 9 publications

References 66 publications

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection

IL-26 in the Lung and Its Role in COPD Inflammation

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