volume 190, issue 10, P5306-5312 2013
DOI: 10.4049/jimmunol.1300016
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Lauren A. Zenewicz, Xiaochen Yin, Guoyang Wang, Eran Elinav, Liming Hao, Liping Zhao, Richard A. Flavell

Abstract: Interleukin-22 (IL-22) is a good candidate to play a critical role in regulating gut microbiota because it is an important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 participates into immune homeostasis by way of modulating gut microbiota remains to be elucidated. In this study, we find through 16S rRNA gene pyrosequencing analysis that healthy IL-22 deficient mice had altered colonic microbiota, notably with decreased abundance of some genera including Lactobacillus and i…

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