IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

Otsuka, Yuto; Kondo, Takao; Aoki, Hiromasa; Goto, Yoh; Kawaguchi, Yohei; Waguri-Nagaya, Yuko; Miyazawa, Ken; Goto, Shigemi; Aoyama, Mineyoshi

doi:10.1016/j.jphs.2022.10.007

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…To further study the reason that composite particles could prove the recruitment of BMSC through cascade reaction, the secretion of chemokines SDF-1 as well as HGF was detected by Elisa kit under P-CM condition. HGF secretion promotes MSC migration via the HGF/c-Met signaling pathway. , In addition, SDF-1 is a stem cell chemokine receptor that promotes stem cell migration via the SDF-1/CXCR4 axis. − Relative expression of HGF and SDF-1 from BMSCs cocultured with particles on 5 days are shown in Figure g,h. Compared with CPP, ECPP particles significantly enhanced the secretion of both HGF and SDF-1 from BMSCs due to the release of Eu ions.…”

Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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Modulating both inflammation and stem cells by designing an artificial joint material to obtain the continuous prevention and control on aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound method and spark plasma sintering (SPS) method. The prepared particles were used to modulate the inflammatory response and further obtain cascade regulation on the proliferation, recruitment, and differentiation of stem cells. The results showed that particles obtained by SPS had a stronger effect on promoting the proliferation and differentiation of stem cells, while by ultrasound method more stem cells were recruited. Besides, the graphene and Eu3+ contained in the particles obtained by SPS method could effectively play a synergistic role on the differentiation of stem cells. In vivo experiment results demonstrated that the composite particles effectively suppress the inflammatory response, recruit stem cells, and prevent AL by inhibiting the secretion of inflammatory factors.

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Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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“…While the differentiation and activation of osteoclasts are primarily governed by M-CSF and RANKL, a plethora of evidence supports the existence of proinflammatory factors, such as TNF, IL-1, IL-6, and IL-17, profoundly enhance osteoclastogenesis. [45][46][47][48] The production of these proinflammatory cytokines stems from a repertoire of activated inflammatory cells, which subsequently elicit activation in other cellular lineages. [49][50][51] Over time, the intricate interplay between inflammatory cells and the skeletal framework exerts a profound impact on the process of bone resorption.…”

Section: Osteoclasts In Inflammatory Bone Lossmentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon us more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, we list the advances of biomaterials for ameliorating inflammatory bone loss. Additionally, we summarize the advantages and disadvantages of various biomaterials‐mediated strategies. Finally, we analyze the challenges and perspectives of biomaterials. This review aims to provide new possibilities for developing more advanced biomaterials towards inflammatory bone loss.This article is protected by copyright. All rights reserved

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“…In vitro human RA studies and in vivo models of arthritis suggest that macrophages and fibroblast-like synoviocytes (FLS) produce IL-6, which in turn promotes the production of RANKL [ 11 •, 35 , 36 ]. Inflammatory macrophages in RA and PD also produce IL-1 that promotes osteoclast differentiation in combination with TNF [ 37 , 38 ] and indirectly by stimulating the recruitment of osteoclast precursors through IL-8 and CCL2 [ 39 – 41 ]. Further, other studies have shown that IL-1 can increase osteoclast activity on its own [ 42 ].…”

Section: Bone Erosion In Ra and Pdmentioning

confidence: 99%

Neutrophils in Inflammatory Bone Diseases

Carmona-Rivera,

Kaplan,

O’Neil

2024

Curr Osteoporos Rep

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Purpose of Review In this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to local bone structures. Recent Findings Neutrophil infiltration is a hallmark of inflammatory bone diseases such as rheumatoid arthritis (RA) and periodontitis disease (PD). Both of these human diseases are marked by an imbalance in bone homeostasis, favoring the degradation of local bone which ultimately leads to erosions. Osteoclasts, a multinucleated resident bone cell, are responsible for facilitating the turnover of bone and the bone damage observed in these diseases. The involvement of neutrophils and neutrophil extracellular trap formation have recently been implicated in exacerbating osteoclast function through direct and indirect mechanisms. We highlight a recent finding that NET proteins such as histones and elastase can generate non-canonical, inflammatory osteoclasts, and this process is mediated by post-translational modifications such as citrullination and carbamylation, both of which act as autoantigens in RA. Summary It appears that NETs, autoantibodies, modified proteins, cytokines, and osteoclasts all ultimately contribute to local and permanent bone damage in RA and PD. However, more studies are needed to fully understand the role of neutrophils in inflammatory bone diseases.

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IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

Cited by 9 publications

References 33 publications

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Neutrophils in Inflammatory Bone Diseases

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