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Cited by 46 publications
(37 citation statements)
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“…Relationship between the IL10 family member genes IL19 and IL20 and recurrent wheeze after RSV LRTI or any other chronic airway disease have not yet been described in literature. Of the two other studies that reported on genetic susceptibility of recurrent wheeze after RSV LRTI, one study showed no association (6). The other study of Goetghebuer et al (5) reported an association between the IL8 -251 C3 T polymorphism and recurrent wheeze, which we could not confirm.…”
Section: Discussioncontrasting
confidence: 59%
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“…Relationship between the IL10 family member genes IL19 and IL20 and recurrent wheeze after RSV LRTI or any other chronic airway disease have not yet been described in literature. Of the two other studies that reported on genetic susceptibility of recurrent wheeze after RSV LRTI, one study showed no association (6). The other study of Goetghebuer et al (5) reported an association between the IL8 -251 C3 T polymorphism and recurrent wheeze, which we could not confirm.…”
Section: Discussioncontrasting
confidence: 59%
“…However, Goetghebuer et al analyzed the occurrence of wheeze after RSV LRTI in infants with a mean age of 6.5 y, whereas our study focused on recurrent wheeze during the first year after RSV LRTI only. These differences in wheeze phenotypes might have influenced the results because our previous study suggested that recurrent wheeze during the first year after RSV LRTI and recurrent wheeze at the age of 6 y are distinct entities with distinct immunological and genetic characteristics (6).…”
Section: Discussionmentioning
confidence: 99%
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“…Both cytokines induce similar biological functions, partly because of their signaling through the IL-4 receptor (IL-4R) a-chain [10]. IL-13 is responsible for RSV-induced airway hyperresponsiveness (AHR) in children [11]. Ermers et al [11] prospectively followed a cohort of 101 children hospitalized for RSV LRI for 6 years, and evaluated the genetic polymorphisms.…”
Section: Genetic Polymorphisms Of Cytokinesmentioning
confidence: 99%
“…IL-13 is responsible for RSV-induced airway hyperresponsiveness (AHR) in children [11]. Ermers et al [11] prospectively followed a cohort of 101 children hospitalized for RSV LRI for 6 years, and evaluated the genetic polymorphisms. They found a significant overrepresentation of the IL-13 Gln-allele (IL-13 Arg130Gln/Gln130Gln) polymorphism in children with late wheezing, but it was not associated with early wheezing.…”
Section: Genetic Polymorphisms Of Cytokinesmentioning
confidence: 99%