IL-10 promoter polymorphisms influence disease severity and course in psoriasis

Abstract

We analyzed three single-nucleotide polymorphisms (SNPs) at the interleukin-10 (IL-10) 5 0 flanking region (positions À1082 A/ G, À819 C/T and À592 C/A) in an association case-control study involving 248 patients with plaque type of psoriasis and 148 unrelated healthy volunteers using ARMS (amplification refractory mutation system)-PCR (Polymerase Chain Reaction) method. No difference was found in the frequencies of haplotype distribution between healthy controls and patients with psoriasis. There were no significant differences in the IL-10 haplotype distribution depending on the age of onset and family history of psoriasis. However, the results of our study demonstrate that the IL-10 haplotype has a role in determining severity and course of plaque type of psoriasis. IL-10 ACC haplotype (Po0.05) is likely to be defining lower activity of disease (PASIr20; extentr10%) and ATA haplotype is likely to be associated with persistent eruption (Po0.01). As ACC haplotype is suggested to be associated with high IL-10 secretion and ATA is related to low IL-10 secretion, potential differences in the IL-10 secretion levels might contribute the differences in the clinical course of psoriasis.

Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

“…In some instances, however, the removal of IL-10 during an infection results in inflammation-associated death, highlighting the critical immunosuppressive role of IL-10 in vivo. Polymorphisms in the human IL-10 promoter have also been linked to altered susceptibility (35,40,66,85,98,107), supporting the findings in animal models. In general, the absence of IL-10 leads to extended survival after infection that is associated with an enhanced adaptive immune response, including CD4 T cell IFN-␥ production and improved control of infection as the normal proinflammatory responses are extended or enhanced.…”

Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis

“…19 We demonstrated previously that IL-10 promoter polymorphisms influence clinical course of plaque-type psoriasis. 20 Hensen et al 21 observed the protective effect of the microsatellite marker IL-10.G9 allele 3 from the IL-10 promoter region to familial psoriasis.…”

Psoriasis: genetic associations and immune system changes

“…97 Protective effects conferred by some alleles and haplotypes within this cluster of genes has also been proposed, along with suggestions that some alleles influence severity or clinical course of disease. 98,99 A comprehensive association analysis of alleles and haplotypes within this cluster of genes is warranted in other patient populations.…”