Amit Saxena, Wei Chen, Ya Su, Vikrant Rai, Olisambu U. Uche, Na Li, Nikolaos G. Frangogiannis
In the infarcted myocardium, activation of the inflammatory cascade clears the wound from dead cells, while stimulating matrix degradation and chamber dilation, thus contributing to the development of heart failure. IL-1 is critically involved in the post-infarction inflammatory reaction and mediates adverse dilative remodeling. We hypothesized that IL-1 may regulate post-infarction repair and remodeling through cell-specific actions on leukocytes and fibroblasts. Flow cytometry demonstrated that in mouse inf…
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