volume 191, issue 9, P4838-4848 2013
DOI: 10.4049/jimmunol.1300725
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Amit Saxena, Wei Chen, Ya Su, Vikrant Rai, Olisambu U. Uche, Na Li, Nikolaos G. Frangogiannis

Abstract: In the infarcted myocardium, activation of the inflammatory cascade clears the wound from dead cells, while stimulating matrix degradation and chamber dilation, thus contributing to the development of heart failure. IL-1 is critically involved in the post-infarction inflammatory reaction and mediates adverse dilative remodeling. We hypothesized that IL-1 may regulate post-infarction repair and remodeling through cell-specific actions on leukocytes and fibroblasts. Flow cytometry demonstrated that in mouse inf…

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