II Diretrizes Brasileiras de Fibrilação Atrial

Study of Dabigatran Use in a Brazilian Public Hospital Specialized in Cardiology

“…Therefore, treatment includes the use anticoagulants. [1][2][3] Dabigatran etexilate, a prodrug, is quickly converted into dabigatran, an anticoagulant that directly and reversibly inhibits thrombin, impeding the conversion of fibrinogen into fibrin. [4][5][6] Doses of 110 mg and 150 mg of dabigatran etexilate, to prevent stroke in patients with atrial fibrillation, were approved by the FDA in 2010, and by the EMA and ANVISA in 2011.…”

Atrial fibrillation with high ventricular rate in emergency room: What’s the best strategy for treatment?

“…It is higher among men compared with women (1.1% x 0.8%); and among white compared with black individuals (2.2% x 1.5%). 2,4,5 Arterial hypertension (SAH) and coronary artery disease (CAD) (post acute myocardial infarction or ischemic cardiomyopathy) are the most common comorbidities present in patients with AF in developed countries. Rheumatic heart disease, although currently uncommon in developed countries, has a much greater association with AF.…”

“…It increases mortality between 1.5 and 1.9 times on the account of hemodynamic deterioration caused by increased heart rate (HR), loss of atrioventricular (AV) synchrony and progressive dysfunction of the left atrium and ventricle, in addition to increasing the risk of stroke and other embolic events triggered by atrial thrombi. [1][2][3][4][5] The risk of developing AF increases with age and with the presence of structural heart disease. Prevalence increases from 0.1% in adults less than 55 years to 8% in those aged 80 years or older.…”

“…AF is an infrequent form of manifestation of acute myocardial infarction or ischemia in the absence of other signs and symptoms of CAD. [1][2][3][4][5] AF and heart failure (HF) often occur together, and a cause and effect relationship between the two is common. In addition, AF is associated with pulmonary disorders including chronic obstructive pulmonary disease (COPD) and pulmonary embolism.…”

“…[1][2][3] AF can lead to a significant reduction in the functional status and quality of life of the affected patients. It increases mortality between 1.5 and 1.9 times on the account of hemodynamic deterioration caused by increased heart rate (HR), loss of atrioventricular (AV) synchrony and progressive dysfunction of the left atrium and ventricle, in addition to increasing the risk of stroke and other embolic events triggered by atrial thrombi.…”