IgM class antitreponemal antibody in treated and untreated syphilis.

O’Neill, Philip D.; Nicol, C. S.

doi:10.1136/sti.48.6.460

Cited by 44 publications

(33 citation statements)

References 17 publications

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“…During the first several weeks of leutic infection, the immune response is suppressed (29,30), and the antibody response is restricted to a few polypeptides (31,32). In tertiary syphilis, as in Lyme disease, specific IgM has been detected after the development of specific IgG, although the responsible antigens have not been identified in syphilis (33,34). Similarly, in certain chronic parasitic infections, immunosuppression occurs in the illness (35), and specific IgM responses have been detected in the presence ofspecific IgG (35).…”

Section: Methodsmentioning

confidence: 93%

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Craft¹,

Fischer²,

Shimamoto³

et al. 1986

J. Clin. Invest.

355

174

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Using immunoblots, we identified proteins ofBorrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were restricted primarily to a 41-kD antigen. This limited response disappeared within several months. In contrast, among six patients with prolonged illness, the IgM response to the 41-kD protein sometimes persisted for months to years, and late in the illness during arthritis, a new IgM response sometimes developed to a 34-kD component of the organism. The IgG response in these patients appeared in a characteristic sequential pattern over months to years to as many as 11 spirochetal antigens. The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.

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Section: Methodsmentioning

confidence: 93%

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Craft¹,

Fischer²,

Shimamoto³

et al. 1986

J. Clin. Invest.

355

174

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show abstract

“…[3][4][5][6][7][8][9] In contrast, Duncan and Kuhn,'°in a similar study using chimpanzees, found that production of specific antitreponemal IgM ceased spontaneously in 10 out of 24 animals who had received no treatment, and treponemal IgM reactivity in sera from patients with late syphilis.…”

Section: Introductionmentioning

confidence: 99%

Immunological responses in late syphilis.

Shannon¹,

Copley²,

Morrison³

1980

Sexually Transmitted Infections

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“…This approach may yield increased specificity over screening by RPR (3) and allows clinical laboratories to meet growing test volumes due to the ability to automate EIAs. Although testing for treponema-specific IgG-class antibodies is most common, the detection of IgM-class antibodies may also be useful when evaluating patients with suspected early disease or congenital syphilis (10,11,13,14,16,18,20).…”

mentioning

confidence: 99%