2011
DOI: 10.1016/j.imlet.2011.05.006
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Abstract: IgG avidity assays have been developed for several parasitic diseases although there are no researches focused in strongyloidiasis diagnosis. Definitive diagnosis of strongyloidiasis is based on the presence of Strongyloides larvae in stool, but majority of cases involve low and irregular larval output. While limitations of serological assays for strongyloidiasis are well known, characteristics of persons who are misdiagnosed based on negative coproparasitological tests have been little explored. The aim of th… Show more

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Cited by 35 publications
(33 citation statements)
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“…The AI cut-off value for low and high avidity was determined to be ≤31% and ≥32% (Narita et al, 1998). In addition, IgG avidity testing was found to be useful in the differential serodiagnosis of recent and distant infections, such as toxocariasis (Dziemian et al, 2008;Delgado et al, 2011), strongyloidiasis (Gonzaga et al, 2011), cytomegalovirus infection (Dollard et al, 2011, brucellosis (Pabuccuoglu et al, 2011) and salmonellosis (Hansen et al, 2006). In previously reported acute human strongyloidiasis, an AI cut-off value was established at 75%, active infection, with an AI for IgG <75%, while the IgG AI in chronic infection was >75% (Gonzaga et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The AI cut-off value for low and high avidity was determined to be ≤31% and ≥32% (Narita et al, 1998). In addition, IgG avidity testing was found to be useful in the differential serodiagnosis of recent and distant infections, such as toxocariasis (Dziemian et al, 2008;Delgado et al, 2011), strongyloidiasis (Gonzaga et al, 2011), cytomegalovirus infection (Dollard et al, 2011, brucellosis (Pabuccuoglu et al, 2011) and salmonellosis (Hansen et al, 2006). In previously reported acute human strongyloidiasis, an AI cut-off value was established at 75%, active infection, with an AI for IgG <75%, while the IgG AI in chronic infection was >75% (Gonzaga et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…The avidity was expressed as an avidity index (AI)% and calculated by taking the difference of OD630 values between positive serum samples (collected from immunised and naturally infected animals) and the negative control sample rather than only positive samples (Gonzaga et al, 2011) The cut-off value of the AI between the two groups (vaccinated and naturally infected animals) was determined by receiver operating characteristic (ROC) analysis at the point where both the sensitivity and specificity were the highest.…”
Section: Establishment Of Indirect Elisamentioning
confidence: 99%
“…Several immunological tests, such as ELISA, western blot, immunofluorescence and luciferase immunoprecipitation system (LIPS), have also been described for the diagnosis of strongyloidiasis [27][28][29]. These assays show variable sensitivity and specificity, depending on the antigen used (crude extract or recombinant antigens) and population tested [27,30].…”
Section: Diagnosismentioning
confidence: 99%
“…Na infecção experimental por S. venezuelensis, o diagnóstico parasitológico tem sido efetuado por meio de exame direto, cultura das fezes em carvão (Paula et al, 2013), e principalmente pela contagem de ovos nas fezes (Nakai e Amarante, 2001;Fernandes et al, 2008;Gonçalves et al, 2011 (Gonzaga et al, 2011).…”
Section: Discussionunclassified
“…Diversas preparações têm sido avaliadas para a pesquisa de anticorpos específicos para o diagnóstico da estrongiloidíase humana Gonzaga et al, 2011;Gonçalves et al, 2012a;Corral et al, 2015). No presente trabalho foi utilizado o extrato alcalino de larvas L3 de S. venezuelensis para a pesquisa de anticorpos no modelo experimental, assim como Gonçalves et al Como o objetivo principal de estudos com modelos experimentais é a aplicação de amostras humanas, e assim chegar a métodos de diagnósticos cada vez mais sensíveis e específicos.…”
Section: Discussionunclassified