2020
DOI: 10.1080/15476286.2020.1812894 View full text |Buy / Rent full text
|
|

Abstract: Epithelial-to-mesenchymal transition (EMT) is a hallmark of aggressive, mesenchymal-like high-grade serous ovarian carcinoma (HGSOC). The SRC kinase is a key driver of cancer-associated EMT promoting adherens junction (AJ) disassembly by phosphorylation-driven internalization and degradation of AJ proteins. Here, we show that the IGF2 mRNA-binding protein 1 (IGF2BP1) is up-regulated in mesenchymal-like HGSOC and promotes SRC activation by a previously unknown protein-ligand-induced, but RNA-independent mechani… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance
0
0
0
0
0
0
6
0

Publication Types

Select...

Relationship

0
0

Authors

Journals