1983
DOI: 10.1001/archderm.119.1.31
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IgE and IgD concentrations in patients with recurrent aphthous stomatitis

Abstract: Serum IgE and IgD concentrations were examined in 80 patients with recurrent aphthous stomatitis (RAS), 20 patients with other ulcerative oral disorders, and 39 control subjects. both IgE and IgD concentrations were substantially greater in patients with RAS than in either the other patients with oral disorders or the control subjects. Although the increased IgE concentrations might be related to cell-mediated phenomena in the immunopathogenesis of RAS and the increased IgD concentrations might support the rec… Show more

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Cited by 12 publications
(10 citation statements)
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“…IgD and IgE concentrations do not appear to have been reported previously in lichen planus but IgD and IgE serum concentrations may be increased in some other oral disorders such as recurrent aphthous stomatitis (Scully, Yap & Boyle, 1982).…”
Section: Discussionmentioning
confidence: 52%
“…IgD and IgE concentrations do not appear to have been reported previously in lichen planus but IgD and IgE serum concentrations may be increased in some other oral disorders such as recurrent aphthous stomatitis (Scully, Yap & Boyle, 1982).…”
Section: Discussionmentioning
confidence: 52%
“…In the present study, we found no correlation between a diagnosis of RAS and medications, food, or drinks which would indicate that allergens tend not to have a role in the aetiology of RAS. Previous reports have been conflicting with evidence showing that 30-56% of atopic patients (1) suffered from RAS and that serum IgE and IgD concentrations were greater in RAS patients than in either control subjects or patients with other oral ulcerative conditions (9).…”
Section: Discussionmentioning
confidence: 95%
“…There may also be associations with immunologically related diseases, such as immunodeficiencies, various allergies and atopic disease (8). Serum IgE concentrations are greater in RAS patients than in either control subjects or patients with other oral ulcerative conditions (9) and from 30% to 56% of atopic patients suffer from RAS (1). The possible association between atopy and RAS is of particular interest, as one factor in the development of the immune system and immunologically related diseases such as atopy may be breast-feeding.…”
Section: Introductionmentioning
confidence: 99%
“…Serum concentration levels of IgE and IgD are significantly greater in RAS patients compared to control groups (59). It is possible that the higher serum IgE concentrations in patients with RAS represent a mild allergic response to as yet unidentified allergens.…”
Section: Immune Disturbancesmentioning
confidence: 89%