IgD Multiple Myeloma: A Report of Five Cases

The Structure and Biology of Human IgD

“…About 1 % of the patients with multiple myeloma produce an IgD myeloma protein (Jancelewicz et al 1975). In our first series of ISO myeloma cases we detected five IgD patients (2.82%) (Fishkin et al 1970); however, we have since typed sera from 1150 myeloma patients and only 14 (1.3 %) showed an IgD para protein. Clinically, IgD myeloma patients have an aggressive course (average survival 13.7 months) like the myeloma patients producing only light chain.…”

IgE myeloma: a case presentation and a review of the literature

“…Anemia does not affect the prognosis for the patient with multiple myeloma (44). Both leukopenia (leukocytes v4610 9 /L) and leukocytosis (leukocytes w10610 9 /L) have been reported in patients with IgE myeloma (1,4,5,18,35). Likewise, thrombocytopenia and thrombocytosis may both occur (3 ± 5, 17, 18, 25, 26, 32, 33, 39).…”

“…IgE myeloma has been associated with hematologic malignancies, chronic lymphatic leukemia (6,13) and plasma cell leukemia (5,11). It may also be associated with lung carcinoma (23).…”

“…Bone lesions were reported in 19 out of 38 cases (44). Osteosclerosis has been reported in IgE myeloma (5,14). Osteolytic lesions are common (80%) in patients with multiple myeloma from other immunoglobulins than IgE.…”

Multiple myeloma: some recent developments

“…1969 were characterized by the presence of plasma cell leukaemia, M protein in serum and urine and the absence of skeletal lesions. The patients reported by Fishkin et al (1972) and Rogers et ul. (1977) showed type K M components and widespread osteosclerotic lesions.…”