IgA Nephropathy: An Interesting Autoimmune Kidney Disease

Rajasekaran, Arun; Julian, Bruce A.; Rizk, Dana V.

doi:10.1016/j.amjms.2020.10.003

Cited by 124 publications

(138 citation statements)

References 177 publications

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“…IgA nephropathy (IgAN) is a common glomerular disease and one of the leading causes of end-stage renal diseases ( 59 ). IgAN is an autoimmune disease characterized by IgA immunodeposits within the mesangium of the glomeruli, usually resulting in hematuria and renal functional insufficiency ( 60 ).…”

Section: Iga Nephropathymentioning

confidence: 99%

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Qiu

Liu

et al. 2021

Front. Immunol.

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Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.

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Section: Iga Nephropathymentioning

confidence: 99%

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Qiu

Liu

et al. 2021

Front. Immunol.

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“…IgAN, the most common glomerulonephritis worldwide, has a high risk of progression to ESRD [2]. The progression of IgAN is not completely related to glomerular lesions, for, in some patients with controlled glomerular lesions, the renal function continues to decline, which implies that tubulointerstitial injury may play a role.…”

Section: Discussionmentioning

confidence: 99%

“…The progression of IgAN is not completely related to glomerular lesions, for, in some patients with controlled glomerular lesions, the renal function continues to decline, which implies that tubulointerstitial injury may play a role. The Oxford MEST (interstitial brosis/tubular atrophy, segmental sclerosis, hypercellularity, endocapillary, and mesangial) histologic score in IgAN suggested that T, S, and M lesions are related to the prognosis of the disease [2,17]. Although guidelines recommend histologic risk factors and clinical features so that disease prediction and therapy selection can be applied properly, speci c genes related to glomerular and tubular damage are still poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Speci cally, end-stage renal disease (ESRD) will develop in 20 percent to 40 percent of IgAN patients within 20 years after illness initiation, according to recent research. [1,2].This illness is predominantly prevalent among young individuals between the ages of 20 and 40 years and causes a great burden to individuals and societies [2]. Currently, scholars believe that genetic, environmental, and immune factors together determine the occurrence and development of IgA nephropathy [3], but the precise pathogenic mechanisms have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Identification and Validation of Glomerulotubular Crosstalk Genes Mediating IgA Nephropathy by Integrated Bioinformatics

Bai

2021

Preprint

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BackgroundIgA nephropathy (IgAN), which has been reported as the most prevalent glomerulonephritis globally, is the major contributor to end-stage renal illness. This bioinformatics study aimed to explore glomeruli-tubulointerstitial crosstalk genes and dysregulated pathways relating to the pathogenesis of IgAN. MethodsThe microarray datasets from the Gene Expression Omnibus (GEO) database were searched. Weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) of both glomeruli and tubulointerstitial were conducted individually. The co-expression gene modules of tubulointerstitial and glomeruli were compared via gene function enrichment analysis. Subsequently, the crosstalk co-expression network was constructed via the STRING database and key genes were mined from the crosstalk network. Results583 DEGs and eight modules were identified in glomeruli samples, while 272 DEGs and four modules were in tubulointerstitial samples. There were 119 overlapping DEGs of the two groups. Among the distinctive modules, four modules in glomeruli and one module in tubulointerstitial were positively associated with IgAN. While four modules in glomeruli and two modules in tubulointerstitial were negatively associated with IgAN. The top ten key genes screened by CytoHubba were ITGAM, ALB, TYROBP, ITGB2, CYBB, HCK, CSF1R, LAPTM5, FN1and CTSS. The above genes were all validated using another two datasets, and all of the key genes demonstrated possible diagnostic significance. Conclusionshe crosstalk genes confirmed in this study may provide novel insight into the pathogenesis of IgAN. Immune-related pathways are associated with both glomerular and tubulointerstitial injuries in IgAN. The glomerulotubular crosstalk might perform a role in the pathogenesis of IgAN.

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“…IgA nephropathy (IgAN) is a common form of glomerulonephritis caused by IgA immunoglobulin deposition in the glomerular basement membrane, characterized by mesangial hyperplasia with significant IgG deposition [ 69 ]. The results of Chung-Yao Wu et al showed that Tris DBA significantly ameliorated albuminuria, renal function, and renal pathologies, including glomerular cell proliferation, periglomerular inflammation, sclerosis, and neutrophil infiltration in the renal interstitium, and it reduced mitochondrial ROS production.…”

Section: The Interplay Between Autophagy and Nlrp3 Inflammasome In Iga Nephropathymentioning

confidence: 99%

The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

Ding

Liu

et al. 2021

IJMS

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Autophagy is a highly conserved process of the eukaryotic cell cycle. It plays an important role in the survival and maintenance of cells by degrading organelles, proteins, and macromolecules in the cytoplasm and the circulation of degraded products. The dysfunction of autophagy can lead to the pathology of many human diseases. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and can induce caspase-1 activation, thus leading to the maturation and secretion of interleukin-1beta (IL-1β) and IL-18. It has been reported that the interplay between autophagy and NLRP3 inflammasome is involved in many diseases, including renal diseases. In this review, the interplay between autophagy and the NLRP3 inflammasome and the mechanisms in renal diseases are explored to provide ideas for relevant basic research in the future.

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IgA Nephropathy: An Interesting Autoimmune Kidney Disease

Cited by 124 publications

References 177 publications

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

Identification and Validation of Glomerulotubular Crosstalk Genes Mediating IgA Nephropathy by Integrated Bioinformatics

The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

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