IgA Nephropathy: An Interesting Autoimmune Kidney Disease

Glomerular Galactose‐Deficient IgA1 Deposition in 192 Autopsy Cases in Japan

“…IgAN typically presents at a relatively young age, most often during the second and third decades of life [1], thus it is possible that the prevalence of subclinical IgAN is higher among younger individuals than in older populations. Although we could not find the studies which have shown an increased prevalence of incidental glomerular IgA in patients with cancer, such IgA deposition has been reported more frequently in individuals with pulmonary [24] or liver diseases [15]. Further investigation of glomerular KM55 staining in patients with these comorbidities may help elucidate the true prevalence of subclinical IgAN in the general population.…”

Artemisinins: Promising drug candidates for the treatment of autoimmune diseases

“…Recent advances in understanding the underlying pathophysiology of the disease have supported it as an autoimmune process. To date, there is still no disease‐specific treatment of IgAN 99 . Research on dihydroartemisinin and artemisinin are reported to be taken as promising approaches for IgAN treatment, though the former is limited to the cellular level.…”

Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis

“…The median percentages of global sclerotic glomeruli in the IgAN-I, IgAN-II, IgAVN-I, and IgAVN-II subgroups were 9.7, 35.3, 7.8, and 7.5%, respectively. M and S scores in the Oxford classification [ 1 ] were similar between the IgAN-I and -II subgroups. E1 lesions were observed in 3 patients in the IgAN-I subgroup and 1 in the IgAN-II subgroup.…”