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Cited by 35 publications
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References 24 publications
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“…My findings (tables 3 and 4) suggest that both the IgG and IgA isotypes may be of value in risk assessment for APS. As in the Afro-Americans, the isotype appears to be particularly associated with APS events in my study patients (15).…”
supporting
confidence: 61%
“…Specificity and standardization considerations for the other aCL isotypes apply also to the IgA aCL assay. In patients with collagen disease, IgA aCL associates with thrombocytopenia, skin ulcers and vasculitis, indicating a patient subgroup at risk for specific clinical manifestations (Evidence Level III) [105], and it is highly prevalent in African–American SLE patients [106]. Hence, this isotype appears to identify patient subgroups rather than adding diagnostic power.…”
Section: Iga Aclmentioning
confidence: 99%
“…The occurrence of MAHA in patients with SLE should not be that surprising in view of the endothelial cell and/or vascular damage seen in SLE secondary to immune complex deposition; autoantibodies; platelet abnormalities; and disorders of fibrinolysis, presence of hypertension, and also possible presence of antiphospholipid antibodies, all of which can be seen with SLE exacerbation (13). The specific role of antiphospholipid antibodies requires further study, although in this study population their frequency was similar in both groups with or without MAHA (14,15).…”
Section: Discussionmentioning
confidence: 65%
“…These controversies may be due to the lack of a standardized assay and differences in study design. Furthermore, most patients with IgA aCL Ab are also positive for IgG or IgM aCL . Therefore, it has been recommended that IgA aCL should be examined when both IgG and IgM aCL are negative, despite a strong suspicion of APS .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, IgG-anticardiolipin antibodies, and to a lesser extent IgM-isotypes, are reported to be the highest risk factors for the clinical manifestations of APS. IgA may be the most common isotype in black patients with SLE and primary APS (173,174). IgA may be the most common isotype in black patients with SLE and primary APS (173,174).…”
Section: Measurement Of Anti-phospholipid Antibodiesmentioning
confidence: 99%