Ifosfamide Induced Neurotoxicity Secondary to Concomitant Aprepitant Use

Malhotra, Akshiv; Poiesz, Bernard J.

doi:10.4172/2167-1052.1000114

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Aprepitant, a centrally acting neurokinin-1 receptor antagonist, is used as a selective antiemetic for highly emetogenic chemotherapeutic agents [29]. The potential inhibition of CYP3A4 by aprepitant may increase the level of ifosfamide neurotoxic metabolites, resulting in the accumulation of CAA [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Encephalopathy Associated with Ifosfamide Use in the Treatment of Patient with Diffuse Large B Cell Lymphoma

Ns¹,

Mustafa²

2021

J Neurol Neurobiol

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Ifosfamide-Related Encephalopathy (IRE) is a unique neurotoxic side effect of ifosfamide that can occur during or after its administration. The exact underlying mechanism responsible for the development of IRE is not yet known; however, mitochondrial toxicity from one or more ifosfamide metabolites has been proposed. Most cases of IRE are mild and resolve spontaneously with discontinuation of ifosfamide in addition to supportive care, but some patients progress to severe encephalopathy with the risk of seizure, coma, and even death. Electroencephalogram (EEG) abnormalities with or without apparent clinical neurotoxicity symptoms develop in a high percentage of patients treated with ifosfamide, with diffuse slowing being the most common finding; in addition, generalized periodic discharges, triphasic waves, periods of suppression, and patterns consistent with nonconvulsive status epilepticus have also been reported.

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Section: Discussionmentioning

confidence: 99%

Encephalopathy Associated with Ifosfamide Use in the Treatment of Patient with Diffuse Large B Cell Lymphoma

Ns¹,

Mustafa²

2021

J Neurol Neurobiol

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Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity

et al. 2022

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Ifosfamide-induced encephalopathy in a patient with metastatic fibrosarcoma

Galus

2016

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Ifosfamide is a cytostatic drug commonly used in chemotherapy. One of the common adverse effects resulting from the treatment with ifosfamide is encephalopathy. This paper describes a case study of a 64-year-old patient who suffered from a full-blown encephalopathy as a result of chemotherapy administered during the treatment of fibrosarcoma of the femur. It provides a hypothesis of the mechanism behind toxic effects of ifosfamide on the central nervous system and elaborates on a number of documented ways of preventing aforementioned complications.

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Ifosfamide Induced Neurotoxicity Secondary to Concomitant Aprepitant Use

Cited by 4 publications

References 19 publications

Encephalopathy Associated with Ifosfamide Use in the Treatment of Patient with Diffuse Large B Cell Lymphoma

Encephalopathy Associated with Ifosfamide Use in the Treatment of Patient with Diffuse Large B Cell Lymphoma

Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity

Ifosfamide-induced encephalopathy in a patient with metastatic fibrosarcoma

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