Ifosfamide Extravasation

Mateu, Javier; Alzamora, Mónica; Franco, Mercedes; Buisán, María-José

doi:10.1177/106002809402801106

Cited by 13 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports about local complications such as thrombophlebitis and necrosis after extravasation of CBP agents are rare, comparably old and refer to higher dosages of therapeutic agents [14,15]. The same applies for Etoposide [16,17], Bleomycin [18] and Ifosfamide [19]. …”

Section: Introductionmentioning

confidence: 99%

Cisplatin-Based Chemotherapy for Testicular Germ Cell Tumors: Complication Rates of Peripheral versus Central Venous Administration

Worst

Sautter²,

John³

et al. 2015

Urol Int

View full text Add to dashboard Cite

Objective: Despite the low local toxicity of the used agents, Cisplatin-based chemotherapy (CBP) for patients with testicular germ cell tumors (TGCT) is mostly delivered via a central venous access (CVA). Since 2008, CBP is given peripherally in our hospital. Methods: Medical reports of TGCT patients who received CBP between September 1991 and August 2014 were evaluated. Complications regarding the way of administration (CVA vs. peripheral venous catheter [PVC]) were classified according to the Common Terminology Criteria of Adverse Events. The complication rates were compared using chi square test and propensity score matching. Results: During 288 cycles in 109 patients, 85 complications (29.5%) were observed with similar rates for overall (PVC 31.3%, CVA 29.9%; p = 0.820) and grade I complications (21.3%, 25.4%; p = 0.470). More grade II complications were observed in the PVC group (10.0 vs. 1.5%; p < 0.001). Grade III complications requiring invasive treatment were found only in the CVA group (3.0%; p = 0.120). Using propensity score matching, no differences in overall (p = 0.950), grade I (p = 0.540) and grades II/III (p = 0.590) complications were seen. Conclusion: The peripheral and central administration of CBP has similar overall complication rates. Despite more grade II complications, the peripheral administration of CBP is a safe alternative for TGCT patients. Additionally, no severe grade III complications occurred.

show abstract

Section: Introductionmentioning

confidence: 99%

Cisplatin-Based Chemotherapy for Testicular Germ Cell Tumors: Complication Rates of Peripheral versus Central Venous Administration

Worst

Sautter²,

John³

et al. 2015

Urol Int

View full text Add to dashboard Cite

show abstract

“…Hyaluronidase and chondroitin sulfatase have been used successfully in a growing number of drug extravasations. [17][18][19][20] Hyaluronidase has been known to improve the local situation when nafcillin extravasates, 1 and its use has since been extended to cases involving caustic medications in the absence of local skin infections, cancerous lesions, or other situations contraindicating its use. 21 If hyaluronidase is used, it should be given as soon as an infiltrate is noted and within an hour's period to limit the time tissue is exposed to concentrated extravasated drug.…”

Section: Discussionmentioning

confidence: 99%

Oxacillin-Induced Tissue Necrosis

Fromm

Graham

1999

Ann Pharmacother

View full text Add to dashboard Cite

show abstract

“…In case 1, the amount injected and the dilution were the same used in the cases of cytotoxic extravasation. [20][21][22] In case 2, attention to the wide area affected the number of applications; therefore, the final dose was increased. However, the volume of each application was reduced to minimize the aggression to the area after the extensive inflammatory reaction presented.…”

Section: Discussionmentioning

confidence: 99%