IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by<i>Helicobacter suis</i>infection

Mimura, Takuya; Yoshida, Masaru; Nishiumi, Shin; Tanaka, Hiroshi; Nobutani, Kentaro; Takenaka, Mamoru; Suleiman, Yahaya Ben; Yamamoto, Kōji; Ota, Hiroyoshi; Takahashi, Shinichi; Matsui, Hidenori; Nakamura, Masahiko; Miki, Ikuya; Azuma, Takeshi

doi:10.1111/j.1574-695x.2011.00823.x

Cited by 13 publications

(23 citation statements)

References 31 publications

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“…Further experimental infections of BALB/c and C57BL/6 mice using 9 H. suis strains, showed that all H. suis isolates induced a predominant T-helper (Th)17 response, but only mild upregulation of the Th2 cytokine interleukin (IL)-4, and no upregulation of Th1 markers, including interferon (IFN)-γ [98] . This contrasts with previously published data which showed that H. suis induced a predominantly Th1 local immune response, and IFN-γ had a major role in the gastric inflammatory process [99,102] . A possible explanation for these differences is that previous experimental infection studies have used homogenized gastric specimens from mice, pigs or non-human primates instead of pure bacterial isolates [99,102] .…”

Section: Infectionscontrasting

confidence: 56%

“…This contrasts with previously published data which showed that H. suis induced a predominantly Th1 local immune response, and IFN-γ had a major role in the gastric inflammatory process [99,102] . A possible explanation for these differences is that previous experimental infection studies have used homogenized gastric specimens from mice, pigs or non-human primates instead of pure bacterial isolates [99,102] .…”

Section: Infectionscontrasting

confidence: 56%

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Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Section: Infectionscontrasting

confidence: 56%

Section: Infectionscontrasting

confidence: 56%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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“…Several studies attribute a major role to IFN‐γ, mainly produced by B cells, in gastric lymphoid follicle formation in mice experimentally inoculated with stomach homogenate from H. suis ‐infected animals . This finding, again, partly contradicts the findings obtained when infecting mice with in vitro‐ isolated H. suis strains colonizing pigs …”

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confidence: 94%

Comparative virulence of in vitro‐cultured primate‐ and pig‐associated Helicobacter suis strains in a BALB/c mouse and a Mongolian gerbil model

et al. 2016

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Apart from the cynomolgus monkey-associated strain which was unable of colonizing the stomach of Mongolian gerbils, no substantial differences in virulence were found in rodent models between in vitro-cultured pig-associated, cynomolgus monkey-associated and rhesus monkey-associated H. suis strains. The experimental host determines the outcome of the immune response against H. suis infection, rather than the original host.

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“…Some studies have attempted to characterize the evoked immune response in the mouse, an animal species which has most often been used to model gastric Helicobacter infection. However, because of the fastidious nature of this micro-organism, these experimental infection studies were carried out using impure mucus or homogenized gastric tissue from infected mice, pigs or non-human primates, thus hampering interpretation of these results [18-20]. …”

Section: Introductionmentioning

confidence: 99%

The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori

Flahou

Deun

Pasmans

et al. 2012

Vet Res

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Helicobacter (H.) suis colonizes the stomach of pigs and is the most prevalent gastric non-H. pylori Helicobacter species in humans. Limited information is available on host immune responses after infection with this agent and it is unknown if variation in virulence exists between different H. suis strains. Therefore, BALB/c and C57BL/6 mice were used to compare colonization ability and gene expression of various inflammatory cytokines, as determined by real-time PCR, after experimental infection with 9 different H. suis strains. All strains were able to persist in the stomach of mice, but the number of colonizing bacteria at 59 days post inoculation was higher in stomachs of C57BL/6 mice compared to BALB/c mice. All H. suis strains caused an upregulation of interleukin (IL)-17, which was more pronounced in BALB/c mice. This upregulation was inversely correlated with the number of colonizing bacteria. Most strains also caused an upregulation of regulatory IL-10, positively correlating with colonization in BALB/c mice. Only in C57BL/6 mice, upregulation of IL-1β was observed. Increased levels of IFN-γ mRNA were never detected, whereas most H. suis strains caused an upregulation of the Th2 signature cytokine IL-4, mainly in BALB/c mice. In conclusion, the genetic background of the murine strain has a clear impact on the colonization ability of different H. suis strains and the immune response they evoke. A predominant Th17 response was observed, accompanied by a mild Th2 response, which is different from the Th17/Th1 response evoked by H. pylori infection.

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IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused byHelicobacter suisinfection

Cited by 13 publications

References 31 publications

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Comparative virulence of in vitro‐cultured primate‐ and pig‐associated Helicobacter suis strains in a BALB/c mouse and a Mongolian gerbil model

The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori

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