2021
DOI: 10.1007/s10815-021-02326-7
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Purpose To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality). Methods A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 88 publications
0
2
0
Order By: Relevance
“…Moreover, they could not disentangle whether age acceleration may provide independent information on the quality of the oocytes ( Monseur et al, 2020 ). Apparently in contrast, Christensen et al did not yield any indication of accelerated aging in n = 55 young women with idiopathic early ovarian aging (defined as: minimum two cycles with ≤5 oocytes obtained by ovarian stimulation with at least 250 IU recombinant FSH), when adjusting for chronological age ( Christensen et al, 2021 ). However, the small sample size and the lack of adjustments for other variables (i.e., BMI, smoking) limit the value of the study.…”
Section: Infertilitymentioning
confidence: 90%
“…Moreover, they could not disentangle whether age acceleration may provide independent information on the quality of the oocytes ( Monseur et al, 2020 ). Apparently in contrast, Christensen et al did not yield any indication of accelerated aging in n = 55 young women with idiopathic early ovarian aging (defined as: minimum two cycles with ≤5 oocytes obtained by ovarian stimulation with at least 250 IU recombinant FSH), when adjusting for chronological age ( Christensen et al, 2021 ). However, the small sample size and the lack of adjustments for other variables (i.e., BMI, smoking) limit the value of the study.…”
Section: Infertilitymentioning
confidence: 90%
“…Interestingly, unscheduled telomere attrition has been shown in leukocytes of women with infertility [28,33 ▪ ], together with an increased number of telomeric aberrations [33 ▪ ]. However, another study did not find accelerated aging in leukocytes of women with idiopathic early ovarian aging [34].…”
Section: Ovarian Agingmentioning
confidence: 99%