2019
DOI: 10.1016/j.jpain.2018.09.004
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Abstract: Chronic pain is associated with maladaptive reorganization of the central nervous system. Recent studies have suggested that disorganization of large-scale electrical brain activity patterns such as neuronal network oscillations in the thalamo-cortical system plays a key role in the pathophysiology of chronic pain. Yet, little is known about if and how such network pathologies can be targeted with non-invasive brain stimulation as a non-pharmacological treatment option. We hypothesized that alpha oscillations,… Show more

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Cited by 75 publications
(106 citation statements)
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“…Emerging evidence shows an inverse relationship between alpha power and chronic pain Ahn et al 2019). Therefore, alpha activity has been proposed as a key target for novel neuromodulatory therapies to manage chronic pain (M. P. Jensen et al 2008).…”
Section: Discussionmentioning
confidence: 99%
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“…Emerging evidence shows an inverse relationship between alpha power and chronic pain Ahn et al 2019). Therefore, alpha activity has been proposed as a key target for novel neuromodulatory therapies to manage chronic pain (M. P. Jensen et al 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Somatosensory alpha activity during pain (Hauck et al 2015) and the anticipation of pain (May et al 2012) is modulated by attention, and frontal alpha activity is increased following a placebo-induced expectation of pain relief (Huneke et al 2013). Importantly, pre-stimulus somatosensory alpha power is inversely related to perceived pain: higher alpha power is associated with lower pain intensity and vice versa, both for experimental pain (Tu et al 2016;Babiloni et al 2006) and chronic pain Ahn et al 2019). Thus, neurotherapies that increase alpha power may have potential in reducing chronic pain.…”
Section: Introductionmentioning
confidence: 99%
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“…Only one study has used tACS to investigate a clinical pain disorder reporting enhanced somatosensory alpha oscillations relative to a sham control that were associated with pain relief. 4 Several additional studies using experimental pain models in otherwise healthy individuals have also shown a reduction in pain with tACS. Further development of tACS in pain disorders supported by advances in modeling and combined EEG approaches, represents an emerging innovation in transcranial electrical stimulation for pain beyond standard tDCS.…”
Section: New Developments Targeting Oscillationsmentioning
confidence: 99%
“…As chronic pain is increasingly considered a disorder of brain network function, supported by evidence of abnormal brain oscillations across somatosensory and orbitofrontal‐temporal cortices, the ability of tACS to selectively modulate oscillatory activity within targeted brain networks may be a promising therapeutic approach for pain. Only one study has used tACS to investigate a clinical pain disorder reporting enhanced somatosensory alpha oscillations relative to a sham control that were associated with pain relief . Several additional studies using experimental pain models in otherwise healthy individuals have also shown a reduction in pain with tACS.…”
Section: New Developments Targeting Oscillationsmentioning
confidence: 99%