Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC

Li, Haolin; Fei, Mintian; Zhang, Yi; Xu, Qili; Feng, Rui; Cao, Jing; Qu, Yan; Xiao, Haibing

doi:10.1016/j.gene.2024.148403

Cited by 1 publication

(1 citation statement)

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“…Liu et al suggested that CTBP1-DT was actively expressed in ovarian cancer, promoting malignant cell biological behavior and accelerating tumor progression [ 29 ]. Recent studies clarified that upregulation of CTBP1-DT mediates cellular activity and lipid synthesis in renal clear cell carcinoma, while silencing CTBP1-DT induces apoptosis [ 30 ]. In this study, CTBP1-DT was verified to be enriched in colorectal cancer serum and cells, effectively distinguishing patients from healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Research on lncRNA CTBP1-DT as a potential therapeutic target to regulate cell function in colorectal cancer

Fan,

Xu,

Kuang

2024

Discov Onc

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Background Colorectal cancer, which originates from the human colon or rectum, is one of the leading causes of death worldwide. Timely diagnosis and interventional therapy can significantly improve the prognostic survival of colorectal cancer patients, making regular screening and early detection essential. Aim To investigate the regulatory function of lncRNA CTBP1-DT (CTBP1-DT) on colorectal cancer cells and to assess its diagnostic significance. Methods A total of 102 patients with colorectal cancer and 92 healthy individuals were selected. The levels of CTBP1-DT and microRNA-30a-5p (miR-30a-5p) in serum and cell samples of the above subjects were compared by RT-qPCR. The effects of CTBP1-DT and miR-30a-5p dysregulation on the biological functions of colorectal cancer cells were analyzed via CCK-8, flow cytometry and Transwell assays. In addition, the ability of CTBP1-DT and miR-30a-5p to early identify colorectal cancer patients was determined through ROC curve. Results Serum CTBP1-DT was elevated in patients with colorectal cancer, which was obviously higher than in healthy controls. The expression of serum miR-30a-5p was downregulated in colorectal cancer. Both CTBP1-DT and miR-30a-5p have the value of distinguishing colorectal cancer, and the combined diagnostic ability is higher. Knockdown of CTBP1-DT directly targeted miR-30a-5p to repress cell activity and metastatic ability, whereas deregulation of miR-30a-5p eliminated the above inhibitory effects. Conclusion Overexpression of CTBP1-DT has a certain application potential in the diagnosis of colorectal cancer and may be a therapeutic target for colorectal cancer.

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Section: Discussionmentioning

confidence: 99%