Identification of Tyrosine Kinases Overexpressed in Head and Neck Cancer

Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis

“…Moreover, compared to the early stages, a strong correlation between high PTK6 expression and short survivals was found at advanced stages (P<0.001, Figure 3A and D), indicating that PTK6 might involve in progression and metastasis of NPC. These findings are in accordance with some previous reports, such as breast cancer [47,48], non-small cell lung cancer [33], ovarian cancer [31], colon cancer [20], head and neck cancers [32] and metastatic melanoma cells [34]. …”

MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC)

“…Similar to what has been found in pancreatic cancer, activation of RON is also associated with tumorigenicity and metastasis of various other forms of human malignancy, such as bladder cancer, head and neck squamous cell carcinomas, breast cancer, ovarian cancer, and colorectal cancer (Chen et al, 2000; Zhou et al, 2003; Lin et al, 2004; Cheng et al, 2005; Lee et al, 2005). In particular, MSP has been shown to increase the invasive behavior and resistance to apoptosis in non-small cell lung cancer (Willett et al, 1998), as well as bone metastasis in breast cancer (Bhatt et al, 2007; Welm et al, 2007).…”

Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma

“…Unlike their premalignant counterparts, HNSCCs expressed predominantly the functional form of Ron. Although there were previous reports that showed Ron expression in over 50% of primary HNSCCs (Lin et al , 2004; Yoon et al , 2012), the sample sizes were small in these studies ( n =8 and 28, respectively); in addition, the methodology of detection did not have a high specificity as the IPW method and is unable to distinguish between the functional and the precursor form of Ron. Thus, this is the largest translational study to examine Ron as a biomarker in HNSCCs.…”