Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption

González, Ana; Gálvez, Natividad; Martín, Jesús; Reyes, Fernando; Pérez-Victoria, Ignacio; Domínguez‐Vera, José M.

doi:10.1016/j.foodchem.2017.02.008

Cited by 66 publications

(68 citation statements)

References 22 publications

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“…The exact mechanism of this process is not well understood. Previous studies revealed that this inverse relationship can be probably due to increased iron absorption by the gut microflora . Moreover, Lactobacillus does not need iron for its development, so it can exist in iron‐deficient state .…”

Section: Human Studiesmentioning

confidence: 99%

“…UA inhibits reactive oxygen species (ROS) production, and its increased synthesis positively influences the host's health state by protecting the host from oxidative stress and inflammation . Moreover, Lactobacillus fermentum present in the gut microflora, due to excreted p ‐hydroxyphenyllactic acid, shows a ferric‐reducing activity that enables the reduction of Fe(III) to Fe(II) . Fe(II), unlike Fe(III), can be absorbed by the host's enterocytes .…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…14 Moreover, Lactobacillus fermentum present in the gut microflora, due to excreted p-hydroxyphenyllactic acid, shows a ferric-reducing activity that enables the reduction of Fe(III) to Fe(II). 4 Fe(II), unlike Fe(III), can be absorbed by the host's enterocytes. 54 To sum up, the gut microbiota favorably modifies dietary non-heme iron transformations in the intestine not only by increasing Fe(III) content but also by supporting Fe(III) reduction to Fe(II), which leads to an increase in iron availability.…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…Recent scientific reports have suggested that gut microbes affect many metabolic processes of the host, including its mineral metabolism. The microbiota is involved in the metabolism of calcium, iron, magnesium, selenium, copper, zinc and silver . Both in vitro and animal investigational models are in use.…”

Section: Introductionmentioning

confidence: 99%

“…The intestinal microflora, probiotics and prebiotics significantly influence the bioavailability of minerals. The intestinal microbiota, probiotics and prebiotics can increase the absorption of minerals, especially iron and calcium, or decrease it …”

Section: Introductionmentioning

confidence: 99%

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Association between the gut microbiota and mineral metabolism

2017

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The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals, and the effect of this interaction on the health of the host. The Web of Science database from the years 2013-2017 on this topic was reviewed. Numerous in vitro studies have shown that iron significantly affects the intestinal microbiota. However, Bifidobacteriaceae are capable of binding iron in the large intestine, thereby limiting the formation of free radicals synthesized in the presence of iron, and thus reducing the risk of colorectal cancer. Animal studies have revealed that supplementation with probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human studies have provided evidence of the influence of probiotic bacteria on parathormone, calcium and phosphate levels and thus on bone resorption. Recent studies have produced new information mainly on the impact of the intestinal bacteria on the metabolism of calcium and iron. From a scientific perspective, the most urgent fields that remain to be investigated are the identification of all human gut microbes and new therapies targeting the interaction between intestinal bacteria and minerals. © 2017 Society of Chemical Industry.

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Section: Human Studiesmentioning

confidence: 99%

Section: In Vitro Studiesmentioning

confidence: 99%

Section: In Vitro Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between the gut microbiota and mineral metabolism

2017

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Postbiotics of Lacticaseibacillus paracaseiCECT 9610 and Lactiplantibacillus plantarumCECT 9608 attenuates store‐operated calcium entry and FAK phosphorylation in colorectal cancer cells

Macias‐Diaz,

Lopez,

Bravo

et al. 2024

Molecular Oncology

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Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ stores, is mediated by the endoplasmic reticulum Ca2+ sensors of the stromal interaction molecules (STIM) family [stromal interaction molecule 1 (STIM1) and STIM2] and the Ca2+‐release‐activated Ca2+ channels constituted by Orai family members, with predominance of calcium release‐activated calcium channel protein 1 (Orai1). CRC cells exhibit enhanced SOCE due to remodeling of the expression of the key SOCE molecular components. The enhanced SOCE supports a variety of cancer hallmarks. Here, we show that treatment of the colorectal adenocarcinoma cell lines HT‐29 and Caco‐2 with inanimate Lacticaseibacillus paracasei (CECT9610) and Lactiplantibacillus plantarum (CECT9608) attenuates SOCE, although no detectable effect is seen on SOCE in normal colon mucosa cells. The effect of Lacticaseibacillus paracasei and Lactiplantibacillus plantarum postbiotics was mediated by downregulation of Orai1 and STIM1, while the expression levels of Orai3 and STIM2 remained unaltered. Treatment of HT‐29 and Caco‐2 cells with inanimate Lacticaseibacillus paracasei and Lactiplantibacillus plantarum impairs in vitro migration by a mechanism likely involving attenuation of focal adhesion kinase (FAK) tyrosine phosphorylation. Cell treatment with the Orai1 inhibitor synta‐66 attenuates SOCE and prevents any further effect of Lacticaseibacillus paracasei and Lactiplantibacillus plantarum postbiotics. Together, our results indicate for the first time that Lacticaseibacillus paracasei and Lactiplantibacillus plantarum postbiotics selectively exert negative effects on Ca2+ influx through SOCE in colorectal adenocarcinoma cell lines, providing evidence for an attractive strategy against CRC.

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Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

et al. 2022

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Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short-and long-term health consequences. Among the underlying causes, certainly a reduced dietary intake and/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo studies suggests an increasingly important contribution from the gut microbiome. Commensal microorganisms can in fact regulate the levels of micronutrients, both by intervening in the biosynthetic processes and by modulating their absorption. This short narrative review addresses the pivotal role of the gut microbiome in influencing the bioavailability of vitamins (such as A, B, C, D, E, and K) and minerals (calcium, iron, zinc, magnesium, and phosphorous), as well as the impact of these micronutrients on microbiome composition and functionality. Personalized microbiome-based intervention strategies could therefore constitute an innovative tool to counteract micronutrient deficiencies by modulating the gut microbiome toward an eubiotic configuration capable of satisfying the needs of our organism, while promoting general health.

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Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption

Cited by 66 publications

References 22 publications

Association between the gut microbiota and mineral metabolism

Association between the gut microbiota and mineral metabolism

Postbiotics of Lacticaseibacillus paracaseiCECT 9610 and Lactiplantibacillus plantarumCECT 9608 attenuates store‐operated calcium entry and FAK phosphorylation in colorectal cancer cells

Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

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