Identification of SARS-like coronaviruses in horseshoe bats (Rhinolophus hipposideros) in Slovenia

Rihtarič, Danijela; Hostnik, Peter; Steyer, Andrej; Grom, Jože; Toplak, Ivan

doi:10.1007/s00705-010-0612-5

Cited by 92 publications

(102 citation statements)

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“…Up to present, bat SARSr-CoVs have been discovered in Asia, Europe and Africa (Balboni et al, 2012b;Drexler et al, 2010;He et al, 2014;Lau et al, 2010Lau et al, , 2005Li et al, 2005;Ren et al, 2006;Rihtaric et al, 2010;Yang et al, 2013;Yuan et al, 2010). However, for most of these strains from countries other than China, only partial RdRp fragment were obtained and full-length genome sequences have been determined for only few of them, thus the available genetic information is insufficient to explore the evolution and spread of these SARSr-CoVs.…”

Section: Discussionmentioning

confidence: 99%

“…In 2005, the discovery of novel CoVs related to human SARS-CoVs in Chinese horseshoe bats (genus Rhinolophus), named SARS-related coronaviruses (SARSr-CoVs), provided new clue that bats may be the natural host for SARS-CoV (Lau et al, 2005;Li et al, 2005). Since then, genetically diverse SARSr-CoVs have been discovered in Asia, Europe, and Africa, including China, South Korea, Thailand, Bulgaria, Slovenia, Italy, Luxembourg, Nigeria, and Kenya (Balboni et al, 2012b;Drexler et al, 2010;He et al, 2014;Lau et al, 2010;Lau et al, 2005;Li et al, 2005;Pauly et al, 2017;Ren et al, 2006;Rihtaric et al, 2010;Yang et al, 2013;Yuan et al, 2010). Importantly, it was reported that some bat SARSr-CoVs were able to use angiotensin converting enzyme II (ACE2) from humans, civets and Chinese horseshoe bats as a receptor originated from Chinese horseshoe bats and suggesting that these SARSr-CoVs had the ability to infect humans immediately without other intermediate hosts.…”

Section: Discovery Of Bat Sars-related Coronaviruses (Sarsr-covs)mentioning

confidence: 99%

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Geographical structure of bat SARS-related coronaviruses

et al. 2019

Infection, Genetics and Evolution

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A B S T R A C TBats are the natural reservoirs of severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the outbreak of human SARS in 2002-2003. We introduce the genetic diversity of SARS-related coronaviruses (SARSr-CoVs) discovered in bats and provide insights on the bat origin of human SARS. We also analyze the viral geographical structure that may improve our understanding of the evolution of bat SARSr-CoVs.

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Section: Discussionmentioning

confidence: 99%

Section: Discovery Of Bat Sars-related Coronaviruses (Sarsr-covs)mentioning

confidence: 99%

Geographical structure of bat SARS-related coronaviruses

et al. 2019

Infection, Genetics and Evolution

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“…Values at deep nodes indicate statistical support from Bayesian posterior probabilities, scale bar genetic distance. or potentially civets (Balboni et al, 2011;Drexler et al, 2010;Lau et al, 2010aLau et al, , 2005Li et al, 2005;Ren et al, 2006;Rihtaric et al, 2010;Yang et al, 2013). These human, civet and bat viruses are now officially summarized by the ICTV in one species, termed SARS-related coronavirus (de Groot et al, 2012).…”

Section: Evidence For Phylogenetic Co-segregation Of Coronaviruses Anmentioning

confidence: 99%

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

2014

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In 2002/2003, a novel coronavirus (CoV) caused a pandemic, infecting more than 8000 people, of whom nearly 10% died. This virus, termed severe acute respiratory syndrome-CoV was linked to a zoonotic origin from rhinolophid bats in 2005. Since then, numerous studies have described novel bat CoVs, including close relatives of the newly emerging Middle East respiratory syndrome (MERS)-CoV. In this paper we discuss CoV genomic properties and compare different taxonomic approaches in light of the technical difficulties of obtaining full genomic sequences directly from bat specimens. We first present an overview of the available studies on bat CoVs, with details on their chiropteran hosts, then comparatively analyze the increase in bat CoV studies and novel genomic sequences obtained since the SARS pandemic. We then conduct a comprehensive phylogenetic analysis of the genera Alpha- and Betacoronavirus, to show that bats harbour more CoV diversity than other mammalian hosts and are widely represented in most, but not all parts of the tree of mammalian CoVs. We next discuss preliminary evidence for phylogenetic co-segregation of CoVs and bat hosts encompassing the Betacoronavirus clades b and d, with an emphasis on the sampling bias that exists among bat species and other mammals, then present examples of CoVs infecting different hosts on the one hand and viruses apparently confined to host genera on the other. We also demonstrate a geographic bias within available studies on bat CoVs, and identify a critical lack of information from biodiversity hotspots in Africa, Asia and Latin America. We then present evidence for a zoonotic origin of four of the six known human CoVs (HCoV), three of which likely involved bats, namely SARS-CoV, MERS-CoV and HCoV-229E; compare the available data on CoV pathogenesis in bats to that in other mammalian hosts; and discuss hypotheses on the putative insect origins of CoV ancestors. Finally, we suggest caution with conclusions on the zoonotic potential of bat viruses, based only on genomic sequence data, and emphasize the need to preserve these ecologically highly relevant animals. This paper forms part of a symposium in Antiviral Research on "from SARS to MERS: 10years of research on highly pathogenic human coronaviruses".

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“…The etiological agent of this disease was found to be a previously unknown coronavirus (SARS-CoV) Fouchier et al, 2003;Ksiazek et al, 2003;Lee et al, 2003;Peiris et al, 2003;Rota et al, 2003). In the last years SARS-CoV like viruses have been found circulating in bats from several continents (Drexler et al, 2010;Lau et al, 2005;Quan et al, 2010;Rihtaric et al, 2010) and bats have been described as putative reservoirs of SARS-CoV (Calisher et al, 2006;Li et al, 2005). Thus, the possibility of SARS reoccurrence remains.…”

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confidence: 99%

Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo

et al. 2012

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The 3'proximal one-third of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes the structural proteins and eight accessory proteins, including 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b, varying in length from 39 to 274aa which do not share significant homology with viral proteins of known coronaviruses. The SARS-CoV protein 6 is 63 amino acids in length and has been previously involved in virus pathogenicity and replication. To further analyze this functions, the interaction of SARS-CoV protein 6 with other viral and/or cellular factors has been analyzed during SARS-CoV infective cycle. Protein 6 immunoprecipitation from extracts of SARS-CoV infected cells and mass spectrometry analysis revealed an interaction of viral proteins 6 and 9b in biologically relevant conditions. This interaction has been reinforced by co-localization of both proteins in the cytoplasm of SARS-CoV infected cells.

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Identification of SARS-like coronaviruses in horseshoe bats (Rhinolophus hipposideros) in Slovenia

Cited by 92 publications

References 50 publications

Geographical structure of bat SARS-related coronaviruses

Geographical structure of bat SARS-related coronaviruses

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo

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