Identification of SARS‐CoV‐2 in the vaginal fluid and cervical exfoliated cells of women with active COVID‐19 infection: A pilot study

Khoiwal, Kavita; Kalita, Deepjyoti; Shankar, Ravi; Kumari, Reena; Dhundi, Deepika; Bahadur, Anupama; Panda, Prasan Kumar; Chaturvedi, Jaya

doi:10.1002/ijgo.13671

Cited by 9 publications

(10 citation statements)

References 6 publications

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“…The blood-testis barrier (BTB) provides an isolated microenvironment and protection for sperm present in the testis [ 64 ]. However, SARS-CoV-2 were recovered from semen samples from acute and recovering male patients but not from vaginal and cervical fluids in females [ 58 , 68 , 69 ]. It is hypothesized that severe inflammation elicited due to an infection can impair the BTB leading to orchitis and/or hypogonadism, severely affecting male fertility and testicular function.…”

Section: Impact On Reproductive System and Fertilitymentioning

confidence: 99%

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Umesh

Pranay

Pandey³

et al. 2022

Infection

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Purpose Apart from the global disease burden of acute COVID-19 disease, the health complications arising after recovery have been recognized as a long-COVID or post-COVID-19 syndrome. Evidences of long-COVID symptoms involving various organ systems are rapidly growing in literature. The objective was to perform a rapid review and evidence mapping of systemic complications and symptoms of long-COVID and underlying pathophysiological mechanisms. Methods Publications reporting clinical trials, observational cohort studies, case–control studies, case-series, meta-analysis, and systematic reviews, focusing on the squeal of the disease, consequences of COVID-19 treatment/hospitalization, long-COVID, chronic COVID syndrome, and post acute COVID-19 were reviewed in detail for the narrative synthesis of frequency, duration, risk factors, and pathophysiology. Results The review highlights that pulmonary, neuro-psychological, and cardiovascular complications are major findings in most epidemiological studies. However, dysfunctional gastrointestinal, endocrine, and metabolic health are recent findings for which underlying pathophysiological mechanisms are poorly understood. Analysis of the clinical trial landscape suggests that more than 50% of the industry-sponsored trials are focused on pulmonary symptoms. In contrast to the epidemiological trends and academic trials, cardiovascular complications are not a focus of industry-sponsored trials, suggestive of the gaps in the research efforts. Conclusion The gap in epidemiological trends and academic trials, particularly concerning cardiovascular complications not being a focus of industry-sponsored trials is suggestive of the gaps in research efforts and longer follow-up durations would help identify other long-COVID-related health issues such as reproductive health and fertility. Supplementary Information The online version contains supplementary material available at 10.1007/s15010-022-01835-6.

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Section: Impact On Reproductive System and Fertilitymentioning

confidence: 99%

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Umesh

Pranay

Pandey³

et al. 2022

Infection

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“…Khoiwal et. al reported the last article on the subject [ 13 ]. They obtained 15 vaginal and 12 cervical swabs from the patients with positive nasal PCR tests, and analysed vaginal samples for SARS-CoV-2 with two different techniques.…”

Section: Discussionmentioning

confidence: 99%

“…All the vaginal samples were negative for SARS-CoV-2 with this technique. In the second technique, vaginal samples were processed for transcription mediated amplification, and detection was performed by nucleic acid hybridization [ 13 ]. Of the 15 vaginal samples, three were positive resulted for SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

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Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study

et al. 2021

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Objective To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed with coronavirus disease-19 (COVID-19) pneumonia. Study design The study was conducted prospectively in a university affiliated hospital. Forty-one women of reproductive age whose nasopharyngeal PCR test were positive for SARS-CoV-2 and clinically diagnosed with pneumonia were included in the study. Vaginal swabs were obtained for SARS-CoV-2 PCR tests when the patients were admitted to the inpatient service before pneumonia treatment was initiated. Results Vaginal swab samples of 38 patients were analysed with SARS-CoV-2 PCR tests. None of the vaginal swabs were positive for SARS-CoV-2. Conclusions SARS-CoV-2 does not infect the vagina of women diagnosed with SARS-CoV-2 pneumonia.

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“…SARS‐CoV‐2 virus was not detected in any sample on RT‐PCR; however, it was identified in 3/15 vaginal samples (20%) by TMA. 7 Therefore, it we decided to process further samples via TMA only in order to enhance the productivity of our research and reduce costs.…”

mentioning

confidence: 99%

Presence of SARS‐CoV‐2 in the lower genital tract of women with active COVID‐19 infection: A prospective study

Khoiwal

Kalita

Kumari

et al. 2022

Intl J Gynecology & Obste

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Identification of SARS‐CoV‐2 in the vaginal fluid and cervical exfoliated cells of women with active COVID‐19 infection: A pilot study

Abstract: Synopsis In women with confirmed COVID‐19, a negative RT‐PCR test result does not rule out the possibility of a low level of SARS‐CoV‐2 in the female genital tract.

Cited by 9 publications

References 6 publications

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is not detected in the vagina: A prospective study

Presence of SARS‐CoV‐2 in the lower genital tract of women with active COVID‐19 infection: A prospective study

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