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Cited by 35 publications
(37 citation statements)
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References 48 publications
(74 reference statements)
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“…Recent studies from our lab have shown that RRM2 expression is both a prognostic and diagnostic biomarker for melanomas with oncogenic BRAF or NRAS [38] and epithelial ovarian cancer (EOC) [53]. In EOC, RRM2 expression positively correlates with the cell proliferation marker Ki67, tumor grade, and stage [53]. We also observed that high RRM2 expression independently predicts a shorter overall survival in both EOC and melanoma patients [53].…”
Section: Nucleotide Metabolism In Cancermentioning
confidence: 59%
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“…Recent studies from our lab have shown that RRM2 expression is both a prognostic and diagnostic biomarker for melanomas with oncogenic BRAF or NRAS [38] and epithelial ovarian cancer (EOC) [53]. In EOC, RRM2 expression positively correlates with the cell proliferation marker Ki67, tumor grade, and stage [53]. We also observed that high RRM2 expression independently predicts a shorter overall survival in both EOC and melanoma patients [53].…”
Section: Nucleotide Metabolism In Cancermentioning
confidence: 59%
“…In EOC, RRM2 expression positively correlates with the cell proliferation marker Ki67, tumor grade, and stage [53]. We also observed that high RRM2 expression independently predicts a shorter overall survival in both EOC and melanoma patients [53]. [38].…”
Section: Nucleotide Metabolism In Cancermentioning
confidence: 91%
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“…A role of carbohydrate metabolism for the maintenance of senescence has been established before. 23,24 The main signaling pathways affected were eIF2, S6Kinase and mTOR signaling. All of these pathways regulate cell growth and proliferation.…”
Section: Discussionmentioning
confidence: 99%