Identification of Q-Markers from Hedan Tablet by employing “spider-web” mode and taking compounds’ hepatotoxicity into account

Wang, Danni; Ding, Jiamin; Feng, Xiafei; Chai, Xin; Yang, Jing; Zeng, Yunhong; Zhou, Wanhui; Wang, Yuefei

doi:10.1016/j.chmed.2021.08.007

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…Additionally, ethnic medicine reveals intricate patterns of “multiple medicines from a single plant” and “one medicine from multiple botanical sources” [ 6 , 7 ]. Consequently, finding a “Rosetta stone” to improve the quality of medicinal materials is a challenging task, especially with the increasing demand for efficacy and safety [ [8] , [9] , [10] ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Yang,

Sima,

Luo

et al. 2024

Journal of Pharmaceutical Analysis

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Section: Introductionmentioning

confidence: 99%

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Yang,

Sima,

Luo

et al. 2024

Journal of Pharmaceutical Analysis

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“…On the one hand, numerous factors, including natural factors and human factors, make the chemical constituents of herbal medicines vary from batch to batch 3 . On the other hand, the characteristics of TCM are systematisation, multi‐target, and multi‐channel, due to the complex chemical components of the medicines 4 . Only a few components are monitored by the traditional quality control methods.…”

Section: Introductionmentioning

confidence: 99%

“…3 On the other hand, the characteristics of TCM are systematisation, multi-target, and multi-channel, due to the complex chemical components of the medicines. 4 Only a few components are monitored by the traditional quality control methods. The holistic nature of TCM is neglected.…”

Section: Introductionmentioning

confidence: 99%

Quality assessment of traditional Chinese medicine using quality biomarkers: Compound DanShen dripping pills as an example

Shen

et al. 2023

Phytochemical Analysis

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Background: The quality control of traditional Chinese medicine (TCM) is one of the main topics in TCM modernisation research. To date, the overwhelming majority of research has focused on chemical ingredients in the quality control of TCM. However, detecting a single or multiple chemical components cannot fully demonstrate the specificity and correlation between quality and efficacy.Purpose: To solve the problem that the association between quality control and efficacy is lacking.The present study was designed to establish a methodology for quality control based on quality biomarkers (Q-biomarkers) and the vasodilatation efficacy of compound DanShen dripping pills (CDDP) as a case.Methods: Guided by the basic principles of Q-biomarkers, the compounds in TCM were determined by ultra-performance liquid chromatography quadrupole time-offlight mass spectrometry. Predicted targets were screened through network pharmacology. The potential Q-biomarkers were further screened through proteomics and partial least squares regression analysis. The protein-protein interaction network that combines both predicted targets and potential Q-biomarkers was constructed to screen Q-biomarkers.Results: There were 32 components and 79 predictive targets for CDDP. Proteomic results indicated that the expression of 23 differential proteins changed as pharmacodynamic and componential changes. CPSF6, RILP11, TMEM209, COQ7, VPS18, PPPP1CA, NF2, and ARFRP1 highly correlated with vasodilation. Protein interaction network analysis showed that NF2 and PPPP1CA were closely related to predicted proteins. Thus, NF2 and PPPP1CA could be considered as Q-biomarkers of CDDP. Conclusion:Our preliminary study suggested the feasibility of the Q-biomarkers theory in the quality of TCM. The concept of Q-biomarkers provided a powerful method to strengthen the link between clinical efficacy and the quality of TCM. In conclusion, a novel, more scientific, and standard quality control method was established in this study.

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“…The main active ingredients (Chen et al, 2011) of HDT are alkaloids, phenolic acids, flavonoids, coumarin, and anthraquinones. These ingredients have effects such as reducing blood lipids, fighting bacteria and viruses, preventing cancer, and protecting against atherosclerosis (Wang et al, 2022). Studies have demonstrated that HDT possesses the ability to ameliorate insulin resistance (Zhao et al, 2013); modulate blood lipid levels (Du et al, 2020); and mitigate hepatocyte swelling, steatosis, necrosis, and inflammatory cell infiltration (Xu et al, 2018).…”

mentioning

confidence: 99%

Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing

Pan,

Zhang,

Qiao

et al. 2024

Biomedical Chromatography

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Obesity is a persistent metabolic condition resulting from the excessive accumulation or abnormal distribution of body fat. This study aimed to establish an experimental rat model of obesity. The efficacy of treating obesity with Hedan tablets (HDT) was assessed by monitoring changes in weight, blood lipid levels, analyzing inflammatory factors, evaluating organ indices, and observing liver tissue pathology. Furthermore, we utilized 16S ribosomal RNA gene sequencing technology to explore changes in intestinal flora. In addition, GC–MS was used to measure fecal short‐chain fatty acid (SCFA) content. The onset of obesity led to a significant decrease in the relative abundance of beneficial bacteria. Conversely, the administration of HDT demonstrated a substantial ability to increase the relative abundance of beneficial bacteria. Obesity resulted in a noteworthy reduction in total SCFAs, a trend significantly reversed in the HDT group. Through correlation analysis, it was determined that HDT mitigated the inflammatory response and improved blood lipid levels by augmenting the abundance of Lactobacillus, Limosilactobacillus, Ruminococcus, and Enterococcus. These particular intestinal flora were identified as regulators of SCFA metabolism, thereby ameliorating metabolic abnormalities associated with obesity. Moreover, HDT intervention elevated the overall fecal concentration of SCFAs, thereby improving metabolic disorders induced by obesity. The anti‐obesity effects of HDT are likely attributable to their capacity to influence the composition of intestinal flora and boost SCFA levels in the intestine.

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Identification of Q-Markers from Hedan Tablet by employing “spider-web” mode and taking compounds’ hepatotoxicity into account

Cited by 5 publications

References 43 publications

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Quality assessment of traditional Chinese medicine using quality biomarkers: Compound DanShen dripping pills as an example

Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing

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