Identification of Potential Drug Targets in Erythrocyte Invasion Pathway of Plasmodium falciparum

Kazan, Mohammad Mustafa; Asmare, Misgana Mengistu; Mahapatra, Rajani Kanta

doi:10.1007/s00284-023-03282-4

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Transcriptomic analysis of xanthoquinodin A1 exposed cultures revealed significant changes in transcripts and GO-terms related to processes such as RNA trafficking, chromosome segregation, and schizogony. While these results do not point to a definitive target, they do appear to be unique for xanthoquinodin A1 compared to known inhibitor DHA and RNASeq datasets generated to identify potential drug targets. − RNASeq analysis of two other fungal-derived antiplasmodials tested alongside xanthoquinodin A1 showed comparatively different transcriptome changes. First, the peptaibol harzianin NPDG I, showed an enrichment in transcripts related to proton transport, translation, and miscellaneous metabolic processes .…”

Section: Discussionmentioning

confidence: 99%

Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1

Collins,

Jiang,

Lee

et al. 2024

ACS Infect. Dis.

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Our previous work identified a series of 12 xanthoquinodin analogues and 2 emodin-dianthrones with broad-spectrum activities against Trichomonas vaginalis, Mycoplasma genitalium, Cryptosporidium parvum, and Plasmodium falciparum. Analyses conducted in this study revealed that the most active analogue, xanthoquinodin A1, also inhibits Toxoplasma gondii tachyzoites and the liver stage of Plasmodium berghei, with no cross-resistance to the known antimalarial targets PfACS, PfCARL, PfPI4K, or DHODH. In Plasmodium, inhibition occurs prior to multinucleation and induces parasite death following 12 h of compound exposure. This moderately fast activity has impeded resistance line generation, with xanthoquinodin A1 demonstrating an irresistible phenotype in both T. gondii and P. falciparum.

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Section: Discussionmentioning

confidence: 99%

Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1

Collins,

Jiang,

Lee

et al. 2024

ACS Infect. Dis.

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“…Protein-protein interaction networks were constructed using the STRING database (version 11.0) with a minimum interaction confidence score of 0.7 (Kazan et al, 2023). The resulting interaction data were imported into Cytoscape software (version 3.8.2) for visualization and analysis.…”

Section: Ppi Networkmentioning

confidence: 99%

Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model

Hong,

Lin,

Fang

et al. 2024

Biomedical Chromatography

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This study investigates the impact of exosomes on bone fracture healing in a rat tibial model, distinguishing between fast and slow healing processes. Bone healing and protein expression were assessed through X‐ray examinations, hematoxylin and eosin staining, and immunohistochemical staining. Exosomes were isolated, characterized and subjected to liquid chromatography–mass spectrometry for protein analysis. Molecular differences were explored using differentially expressed protein analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment and protein–protein interaction networks. Differential bone healing patterns and protein expressions were observed between the control and model groups. Exosomes were successfully isolated and characterized, revealing 2004 identified proteins, including distinct expression profiles. Notably, ribosomal proteins, ferritin and beta‐actin emerged as pivotal players in bone fracture healing. This study unveils dynamic changes in bone healing and underscores the role of exosomes in the process. Identified proteins and pathways offer valuable insights for developing innovative therapeutic strategies for bone healing.

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An Overview of SARS-CoV-2 Potential Targets, Inhibitors, and Computational Insights to Enrich the Promising Treatment Strategies

Kumawat,

Agarwal,

Sharma

2024

Curr Microbiol

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Identification of Potential Drug Targets in Erythrocyte Invasion Pathway of Plasmodium falciparum

Cited by 3 publications

References 45 publications

Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1

Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1

Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model

An Overview of SARS-CoV-2 Potential Targets, Inhibitors, and Computational Insights to Enrich the Promising Treatment Strategies

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