Identification of polymorphisms in cancer patients that differentially affect survival with age

Doherty, Aoife; Kernogitski, Yelena; Kulminski, Alexander M.; Magalhães, João Pedro de

doi:10.18632/aging.101305

Cited by 8 publications

(5 citation statements)

References 122 publications

(126 reference statements)

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“…Individuals differ dramatically in terms of cancer risk even when ‘all else is equal’ (risk factors, sex, age etc. [ 63 ]), and our review suggests that energetic capacity, which differs among individuals may help explain the individuality of cancer risk. Recently, an evaluation of several hypotheses for cancer development revealed that context-dependent selection was necessary and sufficient to explain patterns of cancer incidence, and that individual variation in mechanisms that affect ‘tissue microenvironment’ is the most promising of research directions [ 27 ].…”

Section: Summary and Implications Of Our Hypothesismentioning

confidence: 99%

A novel perspective suggesting high sustained energy expenditure may be net protective against cancer

Biro

Thomas

Ujvari

et al. 2022

Evolution, Medicine, and Public Health

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Energy expenditure (EE) is generally viewed as tumorigenic, due to production of reactive oxygen species (ROS) that can damage cells and DNA. On this basis, individuals within a species that sustain high EE should be more likely to develop cancer. Here, we argue the opposite, that high EE may be net protective effect against cancer, despite high ROS production. This is possible because individuals that sustain high EE have a greater energetic capacity (= greater energy acquisition, expenditure, and ability to upregulate output), and can therefore allocate energy to multiple cancer-fighting mechanisms with minimal energetic tradeoffs. Our review finds that individuals sustaining high EE have greater anti-oxidant production, lower oxidative stress, greater immune function and lower cancer incidence. Our hypothesis and literature review suggest that EE may indeed be net protective against cancer, and that individual variation in energetic capacity may be a key mechanism to understand the highly individual nature of cancer risk.

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Section: Summary and Implications Of Our Hypothesismentioning

confidence: 99%

A novel perspective suggesting high sustained energy expenditure may be net protective against cancer

Biro

Thomas

Ujvari

et al. 2022

Evolution, Medicine, and Public Health

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“…Individuals vary both in their propensity to develop malignant cells and/or in their ability to manage them, for genetic and/or environmental reasons ( Stensrud and Valberg, 2017 ) ( Hochberg and Noble, 2017 ) ( Doherty et al., 2017 ). Individuals within species typically show substantial variation in physiology, behavior, and life history traits that can affect risk of developing cancer and responses to it.…”

Section: Costs At Different Organizational Levelsmentioning

confidence: 99%

Ecological and Evolutionary Consequences of Anticancer Adaptations

et al. 2020

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Summary Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

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“…1,2 It is estimated that by 2050, the elderly population (>60 years old) will account for 22% of the global population (World Health Organization, 2015). 3 Problems with aging populations are becoming increasingly serious; with increasing age, human tissues and the body gradually weaken, and diseases such as high blood pressure, heart disease, and gastrointestinal dysfunction become more prevalent. 4,5 In addition, organ dysfunction gradually appears, the capacity for exercise is reduced, coordination function is lost, and language, perception, movement, and other abilities decline.…”

Section: Introductionmentioning

confidence: 99%

“…As modern society has rapidly developed, the increase in life expectancy has begun to affect human health. , It is estimated that by 2050, the elderly population (>60 years old) will account for 22% of the global population (World Health Organization, 2015) . Problems with aging populations are becoming increasingly serious; with increasing age, human tissues and the body gradually weaken, and diseases such as high blood pressure, heart disease, and gastrointestinal dysfunction become more prevalent. , In addition, organ dysfunction gradually appears, the capacity for exercise is reduced, coordination function is lost, and language, perception, movement, and other abilities decline. , Therefore, the real-time monitoring of vital signs in the elderly and reconstruction of their sensory functions are of great importance. , Real-time monitoring of vital signs, such as body temperature, pulse, respiration, and enzyme activity, can help detect disease in the early stages and prevent deterioration of the body caused by aggressive treatment. , Furthermore, the reconstruction of sensory functions, such as language, sensory function, and motor function, can restore important senses to the elderly and improve their quality of life. , …”

Section: Introductionmentioning

confidence: 99%

A Degradable-Renewable Ionic Skin Based on Edible Glutinous Rice Gel

Tian

Xing

et al. 2022

ACS Appl. Mater. Interfaces

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Traditional wearable devices are commonly nonrecyclable and nondegradable, resulting in energy waste and environmental pollution. Here, a household degradable and renewable ionic skin based on edible glutinous rice gel is developed for a strain, temperature and salivary enzyme activity sensor. This gel depends on intermolecular and intramolecular Hbonds among amylopectin and amylose, and this presents excellent skin-like properties, including stretchability, self-healing property, and adhesion to various substrates. The glutinous rice gel-based skin sensor can be used to monitor vital signs and physiological parameters such as body temperature and heart rate. The sensor also achieves specific speech recognition and detects temperature and body micromovements, which provides the potential to reconstruct language or sensory/motor functions. More importantly, because of the excellent biocompatibility and degradability, the sensor can directly detect the activity of human salivary amylase, which is useful for diagnosing pancreas-, kidney-, and spleen-related diseases in the elderly. Finally, the raw material of ionic skin that originates from traditional grains is degradable and renewable as well as it can be used to prepare household wearable devices. Hence, this work not only extends the application of wearable electronics in daily life but also facilitates health monitoring in the elderly and improves their quality of life.

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Identification of polymorphisms in cancer patients that differentially affect survival with age

Cited by 8 publications

References 122 publications

A novel perspective suggesting high sustained energy expenditure may be net protective against cancer

A novel perspective suggesting high sustained energy expenditure may be net protective against cancer

Ecological and Evolutionary Consequences of Anticancer Adaptations

A Degradable-Renewable Ionic Skin Based on Edible Glutinous Rice Gel

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