2017
DOI: 10.18632/aging.101305
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Abstract: The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progression commonly neglects to account for the ageing process. Herein is the first systematic analysis that combines a large longitudinal data set with a targeted candidate gene approach to examine th… Show more

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Cited by 8 publications
(5 citation statements)
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References 122 publications
(126 reference statements)
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“…Individuals differ dramatically in terms of cancer risk even when ‘all else is equal’ (risk factors, sex, age etc. [ 63 ]), and our review suggests that energetic capacity, which differs among individuals may help explain the individuality of cancer risk. Recently, an evaluation of several hypotheses for cancer development revealed that context-dependent selection was necessary and sufficient to explain patterns of cancer incidence, and that individual variation in mechanisms that affect ‘tissue microenvironment’ is the most promising of research directions [ 27 ].…”
Section: Summary and Implications Of Our Hypothesismentioning
confidence: 99%
“…Individuals differ dramatically in terms of cancer risk even when ‘all else is equal’ (risk factors, sex, age etc. [ 63 ]), and our review suggests that energetic capacity, which differs among individuals may help explain the individuality of cancer risk. Recently, an evaluation of several hypotheses for cancer development revealed that context-dependent selection was necessary and sufficient to explain patterns of cancer incidence, and that individual variation in mechanisms that affect ‘tissue microenvironment’ is the most promising of research directions [ 27 ].…”
Section: Summary and Implications Of Our Hypothesismentioning
confidence: 99%
“…Individuals vary both in their propensity to develop malignant cells and/or in their ability to manage them, for genetic and/or environmental reasons ( Stensrud and Valberg, 2017 ) ( Hochberg and Noble, 2017 ) ( Doherty et al., 2017 ). Individuals within species typically show substantial variation in physiology, behavior, and life history traits that can affect risk of developing cancer and responses to it.…”
Section: Costs At Different Organizational Levelsmentioning
confidence: 99%
“…1,2 It is estimated that by 2050, the elderly population (>60 years old) will account for 22% of the global population (World Health Organization, 2015). 3 Problems with aging populations are becoming increasingly serious; with increasing age, human tissues and the body gradually weaken, and diseases such as high blood pressure, heart disease, and gastrointestinal dysfunction become more prevalent. 4,5 In addition, organ dysfunction gradually appears, the capacity for exercise is reduced, coordination function is lost, and language, perception, movement, and other abilities decline.…”
Section: Introductionmentioning
confidence: 99%
“…As modern society has rapidly developed, the increase in life expectancy has begun to affect human health. , It is estimated that by 2050, the elderly population (>60 years old) will account for 22% of the global population (World Health Organization, 2015) . Problems with aging populations are becoming increasingly serious; with increasing age, human tissues and the body gradually weaken, and diseases such as high blood pressure, heart disease, and gastrointestinal dysfunction become more prevalent. , In addition, organ dysfunction gradually appears, the capacity for exercise is reduced, coordination function is lost, and language, perception, movement, and other abilities decline. , Therefore, the real-time monitoring of vital signs in the elderly and reconstruction of their sensory functions are of great importance. , Real-time monitoring of vital signs, such as body temperature, pulse, respiration, and enzyme activity, can help detect disease in the early stages and prevent deterioration of the body caused by aggressive treatment. , Furthermore, the reconstruction of sensory functions, such as language, sensory function, and motor function, can restore important senses to the elderly and improve their quality of life. , …”
Section: Introductionmentioning
confidence: 99%