2016
DOI: 10.1016/j.gdata.2016.05.012
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Abstract: Genome-wide analysis of DNA methylation has now become a relatively inexpensive technique thanks to array-based methylation profiling technologies. The recently developed Illumina Infinium MethylationEPIC BeadChip interrogates methylation at over 850,000 sites across the human genome, covering 99% of RefSeq genes. This array supersedes the widely used Infinium HumanMethylation450 BeadChip, which has permitted insights into the relationship between DNA methylation and a wide range of conditions and traits. Prev… Show more

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Cited by 248 publications
(141 citation statements)
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“…0.01) within 10bp of the CpG site or single base extension(McCartney et al 2016;Pidsley et al 2016) and probes on the sex chromosomes were excluded from the QTL analysis. In addition, 977 substandard probes identified by Illumina were also excluded.…”
mentioning
confidence: 99%
“…0.01) within 10bp of the CpG site or single base extension(McCartney et al 2016;Pidsley et al 2016) and probes on the sex chromosomes were excluded from the QTL analysis. In addition, 977 substandard probes identified by Illumina were also excluded.…”
mentioning
confidence: 99%
“…Probes with fewer than three beads for either the methylated or unmethylated channel, or with detection P value ≥ 0.01 were removed. Probes on sex chromosomes, cross-hybridising probes [29], and probes with SNPs at the CpG site or its single-base extension were excluded. The number of CpGs excluded at each step is summarised in Supplementary Table A2.…”
Section: Methodsmentioning
confidence: 99%
“…Three samples showed density artefacts after normalization and were removed from further analysis. We excluded any probes on chromosome X or Y, probes containing SNPs and cross-hybridizing probes according to Chen et al 50 , Price et al 51 and McCartney et al 52 .…”
Section: Methylationmentioning
confidence: 99%