1989
DOI: 10.1001/archderm.125.11.1518
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Identification of plasmacytoid T cells in lymphoid hyperplasia of the skin

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Cited by 16 publications
(17 citation statements)
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“…According to the current multistep tumorigenesis theory [14], the nonclonal cellular proliferating nature was therefore not indicative of a neo plastic process, but most likely represented a reactive pro liferation since polyclonal proliferation usually indicates a reactive nature. Plasmacytoid T cell variants were also pre viously found by immunohistochemical methods in some cases of lymphoid hyperplasia of the skin [15], but no plasmacytoid features were noted in our case. In the present case, the flow-cytometric data, the clinical and morpholog ical observations supported a diagnosis of lymphadenosis benigna cutis.…”
Section: Discussionsupporting
confidence: 40%
“…According to the current multistep tumorigenesis theory [14], the nonclonal cellular proliferating nature was therefore not indicative of a neo plastic process, but most likely represented a reactive pro liferation since polyclonal proliferation usually indicates a reactive nature. Plasmacytoid T cell variants were also pre viously found by immunohistochemical methods in some cases of lymphoid hyperplasia of the skin [15], but no plasmacytoid features were noted in our case. In the present case, the flow-cytometric data, the clinical and morpholog ical observations supported a diagnosis of lymphadenosis benigna cutis.…”
Section: Discussionsupporting
confidence: 40%
“…Further experiments are needed to formally decipher this hypothesis. Altogether, this may suggest that CCL20 and CCR6 could play a role in some pathologic situations, [18][19][20]22,24 where normal PDC accumulation has been recently described. The role of CCR4 and CCR10 in this LPDC trafficking to skin remains to be investigated as these chemokine receptors have been demonstrated to be involved in skin-specific CD 4 þ T-lymphocyte homing.…”
Section: Discussionmentioning
confidence: 63%
“…8 In adults, PDC have been found predominantly in blood, 9,10 bone marrow, 10,11 and thymus. 12,13 Interestingly, in several inflammatory situations, PDC have been described in other lymphoid (reactive lymph nodes, 10,14-16 tonsils 17 ) and nonlymphoid organs (skin, [18][19][20][21][22][23] mucosa 24 ). In reactive secondary lymphoid organs, PDC are found mainly nonactivated and located in T-cell area close to the postcapillary high endothelial venules (HEV) suggesting their entrance from blood stream.…”
Section: Introductionmentioning
confidence: 99%
“…Data on the presence of PM in extranodal tissues are limited to cutaneous inflammatory conditions such as pseudolymphomas [30], Jessner's lymphocytic infiltrate [40], lupus erythematosus [45], psoriasis and contact dermatitis [129]. Finally P-DCs accumulate dramatically in nasal mucosa on experimentally induced allergic reaction [72] and were found to infiltrate allergic nasal polyps [118].…”
Section: Pm In Pathological Conditionsmentioning
confidence: 99%