Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons

Moreno-López, Yunuen; Martínez‐Lorenzana, Guadalupe; Condés‐Lara, Miguel; Rojas-Piloni, Gerardo

doi:10.1016/j.npep.2012.09.008

Cited by 73 publications

(67 citation statements)

References 34 publications

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“…OTRs are densely expressed in laminae I and II of the dorsal horn in mouse (Wrobel et al, 2011) and rat (Reiter et al, 1994;Moreno-Lopez et al, 2013). In the mouse (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the report about the presence of OTR in the rat DRG is controversial. In the rat DRG, OTR is expressed predominantly in non-peptidergic C-fiber cell bodies with Isolectin Griffonia simplicifolia (IB4) immunopositive (Moreno-Lopez et al, 2013). IB4-binding neurons are small-sized in DRG giving rise to unmyelinated fibers (Wang et al, 1994), and subserve nociceptor function (Petruska et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the OTR is expressed in the dorsal root ganglia (DRG), principally in non-peptidergic C-fiber cell bodies (Moreno-Lopez et al, 2013). OT inhibition on the increase in intracellular calcium from membrane depolarization and on ATP-activated currents is mediated by OT receptors in membranes of DRG neurons (Yang et al, 2002;Hobo et al, 2012), besides that, our lab has shown that OT could hyperpolarize myenteric intrinsic primary afferent neurons (IPANs) through binding OTR (Che et al, 2012).…”

Section: Introductionmentioning

confidence: 96%

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Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

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“…Preclinical studies have demonstrated that parvocellular oxytocin secreting neurons in the PVN project to the spinal cord and exert a significant effect on neurons expressing oxytocin receptors in the superficial laminae (laminae I/II) of the dorsal horn (Eliava et al, 2016;Moreno-López et al, 2013;Wrobel et al, 2011). Laminae I/II of the dorsal horn is the primary target for both myelinated and unmyelinated afferent fibres that respond to noxious stimulation in the periphery (although it is of note that thinly myelinated and unmyelinated fibres that signal the presence of innocuous mechanical and thermal stimuli also project to these same laminae) (Craig, 2002).…”

Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

et al. 2017

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Low intensity, non-noxious, stimulation of cutaneous somatosensory nerves has been shown to trigger oxytocin release and is associated with increased social motivation, plus reduced physiological and behavioural reactivity to stressors. However, to date, little attention has been paid to the specific nature of the mechanosensory nerves which mediate these effects. In recent years, the neuroscientific study of human skin nerves (microneurography studies on single peripheral nerve fibres) has led to the identification and characterisation of a class of touch sensitive nerve fibres named C-Tactile afferents. Neither itch nor pain receptive, these unmyelinated, low threshold mechanoreceptors, found only in hairy skin, respond optimally to low force/velocity stroking touch. Notably, the speed of stroking which c-tactile afferents fire most strongly to is also that which people perceive to be most pleasant. The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions. In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive affective value and, under healthy conditions, inhibits responses to painful stimuli. These effects mirror those, we also review, which have been reported following endogenous release and exogenous administration of oxytocin. Taken together this evidence suggests c-tactile afferent stimulation may mediate oxytocin release during affiliative tactile interactions.

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“…In recent years, a highly sensitive method for detecting OTR has been developed, and the sites of OTR expression in the spinal cord have been reported to be laminae I-II, intermediomedial/intermediolateral grey matter, lamina X, the parasympathetic nerve region, and the dorsal root ganglion in rats [24,25]. In particular, it is suggested that OTR is abundant in the dorsal horn (laminae I-II) of the spinal cord, which is associated with nociception.…”

Section: Oxytocin and Painmentioning

confidence: 99%

Posterior Pituitary Hormones and Pain

Matsuura

Kawasaki

Sakai³

et al. 2015

IIS

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Vasopressin and oxytocin are well-known neurohypophysial and posterior pituitary hormones that are synthesized in the paraventricular and supraoptic nuclei of the hypothalamus and are secreted from the posterior pituitary into the systemic circulation. It is known that vasopressin plays an important role in maintaining body fluid homeostasis, and that oxytocin plays an essential role in mammalian labor and lactation through its peripheral action. In addition to these classic physiological actions, vasopressin and oxytocin have been attracting considerable attention in recent years because of their effects in their involvement in social recognition, and in the regulation of the cardiovascular system, the central nervous system and stress responses. Their analgesic effects have also been mentioned among these newly-recognized physiological actions. This review focuses on pain modulation by vasopressin and oxytocin.

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Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons

Cited by 73 publications

References 34 publications

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

Posterior Pituitary Hormones and Pain

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