Abstract:Mammary carcinoma, including triple-negative breast carcinomas (TNBC) are tumortypes for which human and canine pathologies are closely related at the molecular level.Low-passage, primary carcinoma cells from TNBC versus non-TNBC were used to compare the efficacy of an oncolytic vaccinia virus (VV). We show that non-TNBC cells are 28 times more sensitive to VV than TNBC cells in which VV replication is impaired.Single-cell RNA-seq performed on two different TNBC cell samples infected or not with VV highlighted… Show more
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