Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia

Ngoc, Phuong Cao Thi; Tan, Shi Hao; Tan, Tze King; Chan, Min Min; Li, Zhenhua; Yeoh, Allen Eng Juh; Tenen, Daniel G.; Sanda, Takaomi

doi:10.1038/s41375-018-0110-4

Cited by 39 publications

(28 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TAL1 overexpression is thought to result in a sequestration of E-proteins into the TAL1-E-protein heterodimer and thus indirectly inhibit the transcription of genes regulated by E-protein-E-protein dimers [70]. In human and mouse T-ALL cells, the expression levels of RAG1, RAG2 and PTCRA are often repressed and can be upregulated after TAL1 knockdown [71][72][73]. Similarly, CD4, TCR-alpha and CD69 genes have been reported to be repressed by TAL1 [49,71,74].…”

Section: Inhibition Of E-protein Functions and Differentiation Blockmentioning

confidence: 99%

See 1 more Smart Citation

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

2018

Self Cite

View full text Add to dashboard Cite

TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Such precise control is crucial for the switching of the transcriptional program. The misexpression of TAL1 in immature thymocytes leads to a widespread series of orchestrated downstream events that affect several different cellular machineries, resulting in a lethal consequence, namely T-cell acute lymphoblastic leukemia (T-ALL). In this article, we will discuss the transcriptional regulatory network and downstream target genes, including protein-coding genes and non-coding RNAs, controlled by TAL1 in normal hematopoiesis and T-cell leukemogenesis.

show abstract

Section: Inhibition Of E-protein Functions and Differentiation Blockmentioning

confidence: 99%

“…Our group has recently performed a comprehensive identification of lncRNAs expressed in TAL1-positive T-ALL cells by developing a bioinformatics pipeline and RNA-seq analysis with deep coverage [73]. We selected a list of putative lncRNAs that are directly activated by TAL1 and their regulatory complex partners.…”

Section: Lncrnas Regulated By Tal1 In T-allmentioning

confidence: 99%

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Increasing evidence has suggested that lncRNAs are vital epigenetic regulators of mRNA expression and constitute an important fraction of the human transcriptome. Furthermore, there is a growing number of studies that have reported that lncRNAs play important roles in tumor genesis, progression, and metastasis, as well as many other cellular processes (13)(14)(15)(16). Aberrant expression of lncRNAs may contribute to glioma pathogenesis, including cellular proliferation, apoptosis, and metastasis (17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas

et al. 2020

View full text Add to dashboard Cite

The aim of the present study was to explore the expression profiles of lncRNAs and mRNAs in glioma patients and to elucidate any potential relationship between lncRNAs and mRNAs in glioma. High-throughput transcriptome sequencing of mRNAs and lncRNAs from six normal tissues and 16 glioma tissues (grade II, six cases; grade III, four cases; and grade IV, six cases) was performed. Series test of cluster (STC) analysis was used to screen significant trending models associated with glioma. Gene co-expression networks were constructed for the differentially expressed lncRNAs and mRNAs, and gene-ontology (GO) and pathway-enrichment analyses were further performed. Quantitative real-time PCR was performed to validate the five most differentially expressed lncRNAs and mRNAs. After filtering the raw sequencing data, we found 578 lncRNAs and 3,216 mRNAs that were significantly dysregulated in glioma (fold change ≥ 2, p < 0.05). Twenty model profiles of lncRNA and 10 model profiles of mRNA were summarized, and three patterns of lncRNAs and two patterns of mRNAs were of clinical significance. Three gene co-expression networks between mRNAs and lncRNAs were built to clarify the relationship between lncRNAs and mRNAs in glioma. GO and pathway analyses indicated that the differentially expressed lncRNAs and mRNAs were enriched in several biological processes and signaling pathways associated with tumorigenesis. Both lncRNAs and mRNAs exhibited dynamic differential expression profiles that indicated their potential roles in different degrees of glioma malignancy. A series of bioinformatics analyses indicated that most of these lncRNAs and mRNAs are involved in important biological processes and pathways associated with the pathogenesis of glioma. These results provide potential directions and valuable resources for future investigations via the comprehensive integration of these lncRNAs and mRNAs.

show abstract

“…A major obstacle to understanding the mechanisms of T-ALL oncogenesis is the heterogeneous cellular and molecular nature of the disease, which is driven by a complex interplay of multiple oncogenic events. In this context, LncRNA signatures have been shown to define oncogenic subtypes [10] and several LncRNAs regulated by key T-ALL oncogenes have been identified [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia

Kermezli

Saadi

Belhocine

et al. 2019

Leukemia & Lymphoma

View full text Add to dashboard Cite

Several studies have demonstrated that LncRNAs can play major roles in cancer development. The creation of a catalogue of LncRNAs expressed in T cell acute lymphoblastic leukemia (T-ALL) is thus of particular importance. However, this task is challenging as LncRNA expression is highly restricted in a time and space manner and may thus greatly differ between samples. We performed a systematic transcript discovery in RNA-Seq data obtained from TALL primary cells and cell lines. This led to the identification of 2560 novel LncRNAs. After the integration of these transcripts into a large compendium of LncRNAs (n=30478) containing both known LncRNAs and those previously described in T-ALLs, we then performed a systematic genomic and epigenetic characterization of these transcript models demonstrating that these novel LncRNAs share properties with known LncRNAs. Finally, we provide evidences that these novel transcripts could be enriched in LncRNAs with potential oncogenic effects and identified a subset of LncRNAs coregulated with TALL oncogenes. Overall, our study represents a comprehensive resource of LncRNAs expressed in TALL and might provide new cues on the role of lncRNAs in this type of leukemia.

show abstract

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia

Cited by 39 publications

References 50 publications

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas

A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia

Contact Info

Product

Resources

About