2007
DOI: 10.1038/nm1656
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Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or individuals with predisposing risk factors. However, recently there has been an alarming epidemic caused by community-associated (CA)-MRSA strains, which can cause severe infections that can result in necrotizing fasciitis or even death in otherwise healthy adults outside of healthcare settings. In the US, CA-MRSA i… Show more

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Cited by 901 publications
(1,496 citation statements)
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“…Using both co-infection and single-strain infection designs in 117 outbred rabbits, no difference in lung, spleen or kidney infectivity were detected using the same MW2 and LAC isogenic strain pairs [52]. As the same mouse and rabbit models have been used successfully to demonstrate the role of other CA-MRSA virulence factors [53,54], the null effect of PVL in these models strongly indicates that this toxin is not a major virulence factor of MW2 and USA300 strains.…”
Section: Pvl and Its Effects As Purified Toxinmentioning
confidence: 99%
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“…Using both co-infection and single-strain infection designs in 117 outbred rabbits, no difference in lung, spleen or kidney infectivity were detected using the same MW2 and LAC isogenic strain pairs [52]. As the same mouse and rabbit models have been used successfully to demonstrate the role of other CA-MRSA virulence factors [53,54], the null effect of PVL in these models strongly indicates that this toxin is not a major virulence factor of MW2 and USA300 strains.…”
Section: Pvl and Its Effects As Purified Toxinmentioning
confidence: 99%
“…Future research on the biological relevance of PVL is cautiously warranted. Nonetheless, attributing enhanced CA-MRSA pathogenicity to PVL alone ignores the possible contributions of numerous other genetic determinants unique to these epidemic strains (Figure 2) [25,26,53,62].…”
Section: Does Pvl Have a Gene Regulatory Effect?mentioning
confidence: 99%
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“…Several international studies have demonstrated that the CA-MRSA isolates are more virulent than the HA-MRSA isolates, due to greater production of virulence factors such as the Panton-Valentine leukocidin (PVL) and the phenol-soluble modulins (PSM), capable of lysing macrophages and neutrophils (5,6). Additionally, the CA-MRSA isolates contains genetic mobile elements that give them greater environmental adaptability--as is the case with the arginine catabolic mobile element (ACME), specifically identified in the USA300 clone (21).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the CA-MRSA isolates have begun to cause infections in hospitalized patients and to replace the clones of hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) (3,4). These isolates differ from the HA-MRSA forms in that they are more virulent and possess genetic components that cause infections even in healthy persons without apparent risk factors or prior contact in a hospital environment (2,5,6). Even though HA-MRSA has been a clinical concern for a long time, the infections caused by CA-MRSA have become the focal point for clinical and researchconcern.…”
mentioning
confidence: 99%