Identification of miRNAs and their potential effects on multiple sclerosis related pathways using ın silico analysis

Erkal, Burçin; Korkut, Şenay Vural

doi:10.1016/j.msard.2022.103642

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…The other transcripts are defined as noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and small noncoding RNAs (smRNAs). Small non-coding RNAs (microRNA, small nuclear RNA, small nucleolar RNA, tRNA derived small RNA and Piwi-interacting RNA) can be considered a relatively new class of molecule that are differentially regulated in many diseases [49]; hence and represent a class of biomarkers to be explored in a variety of contexts [50]. The terms 'micro' and 'small' are seemingly used interchangeably in the literature.…”

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

“…In humans, miRNAs are synthesized from primary miRNAs (pri-miRNAs) in two stages by the action of two RNase III-type proteins: Drosha in the nucleus and Dicer in the cytoplasm [48][49][50][51][52]. The mature miRNAs are then bound by Argonaute (Ago) subfamily proteins.…”

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

“…The mature miRNAs are then bound by Argonaute (Ago) subfamily proteins. These miRNAs target mRNAs and thereby function as posttranscriptional regulators [48][49][50][51][52]. See later regarding the potential effects of mRNA vaccines binding to miRNAs.…”

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

“…miRNAs are powerful regulators of cellular activities including cell growth, differentiation, development, proliferation and death, apoptosis, fat metabolism, neuronal patterning, hematopoietic differentiation, and in immune function [57]. An altered miRNA expression is associated with many human diseases and poor immune function [49,50,52,58,59]. They are also involved in the regulation of autoimmune diseases [60] and oncogenesis [61].…”

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

“…When reading these studies recall that only selected miRNAs are transported out of the cell [66,67] and remain stable in blood [49]. Hence studies on miRNAs in COVID-19 disease severity are measuring a potentially confusing mix of selectively transported miRNAs and miRNAs released by extensive cell lysis in more severe infections.…”

Section: Covid-19 Infection Alters the Mirna Landscape And Ensuing Ge...mentioning

confidence: 99%

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Effect of Age, Sex, and COVID-19 Vaccination History on All-Cause Mortality: Unexpected Outcomes in a Complex Biological and Social System

Jones¹,

Ponomarenko²

2023

Preprint

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All vaccines exhibit both specific and non-specific effects. The specific effects are measured by the efficacy against the target pathogen, while the non-specific effects can be detected by the change in all-cause mortality . All-cause mortality data (gender, age band, vaccination history, month of death) between January 2021 and May 2022 was compiled by the Office for National Statistics. COVID–19 vaccination gave good protection on many occasions but less so for younger ages. Each gender and age group shows its own unique vaccination benefit/disbenefit time profile. Individuals are free to make vaccination decisions. For example, women aged 18-39 show a cohort who do not progress beyond the first or second dose. The all-cause mortality outcomes for the Omicron variant showed a very poor response to vaccination with 70% of sex/age/vaccination stage/month combinations increasing all-cause mortality, probably due to unfavorable antigenic distance between the first-generation vaccines and this variant, and additional non-specific effects. The all-cause mortality outcomes of COVID–19 vaccination is far more nuanced than have been widely appreciated, and virus vector appear better than the mRNA vaccines in this specific respect. The latter are seemingly more likely to increase all-cause mortality especially in younger age groups. An extensive discussion/literature review is included to provide potential explanations for the observed unexpected vaccine effects.

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Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

Section: The Central Role Of Small Non-coding Rnas In Gene Expressionmentioning

confidence: 99%

Section: Covid-19 Infection Alters the Mirna Landscape And Ensuing Ge...mentioning

confidence: 99%

See 3 more Smart Citations

Effect of Age, Sex, and COVID-19 Vaccination History on All-Cause Mortality: Unexpected Outcomes in a Complex Biological and Social System

Jones¹,

Ponomarenko²

2023

Preprint

View full text Add to dashboard Cite

show abstract

Key Genes in Olfactory Disorder in Experimental Autoimmune Encephalomyelitis Identified by Transcriptomic Analysis of the Olfactory Bulbs

Hong,

Kim,

Ahn

et al. 2024

Mol Neurobiol

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Potential nanocarrier-mediated miRNA-based therapy approaches for multiple sclerosis

Sastri

Gupta²,

Kannan³

et al. 2022

Drug Discovery Today

View full text Add to dashboard Cite

Identification of miRNAs and their potential effects on multiple sclerosis related pathways using ın silico analysis

Cited by 8 publications

References 21 publications

Effect of Age, Sex, and COVID-19 Vaccination History on All-Cause Mortality: Unexpected Outcomes in a Complex Biological and Social System

Effect of Age, Sex, and COVID-19 Vaccination History on All-Cause Mortality: Unexpected Outcomes in a Complex Biological and Social System

Key Genes in Olfactory Disorder in Experimental Autoimmune Encephalomyelitis Identified by Transcriptomic Analysis of the Olfactory Bulbs

Potential nanocarrier-mediated miRNA-based therapy approaches for multiple sclerosis

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