1959
DOI: 10.1172/jci103977
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Abstract: Sulfobromophthalein (BSP) is normally cleared from the blood by the liver and excreted into the bile. Brauer, Krebs and Pessotti (1) originally reported that part of the pigment appearing in dog bile was chromatographically different from the injected dye. Our studies using differenlt chromatographic techniques indicate that in man the bulk of the recovered pigments (65 to 75 per cent, according to estimates based on their absorption at 575 nu) consists of two metabolites. Similar metabolites are normally foun… Show more

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Cited by 79 publications
(34 citation statements)
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“…In Patient J.L. the plasma BSP concentration was followed for 24 hours after termination of the actual study. During the first 8 hours it diminished from 19.1 to 13.6 mg per 100 ml.…”
Section: B Normal Manmentioning
confidence: 99%
See 1 more Smart Citation
“…In Patient J.L. the plasma BSP concentration was followed for 24 hours after termination of the actual study. During the first 8 hours it diminished from 19.1 to 13.6 mg per 100 ml.…”
Section: B Normal Manmentioning
confidence: 99%
“…Although it has been shown that a major proportion of BSP appears in the bile in the form of chromotographically distinct conjugates (21)(22)(23)(24), it is apparent that conjugation is not essential for BSP secretion since a considerable amount of unconjugated BSP is also found in all species. However, in view of the constant ratio between the amount of BSP and its conjugates., which was observed during concturrent studies (22), one cannot be certain whether the BSP Tm refers to a single transport mechanism or to the sum of separate transport mechanisms for BSP and each of its conjugates.…”
Section: Toxicitymentioning
confidence: 99%
“…Based on a considerable body of evidence which has been accumulated within the past few years (8)(9)(10)(11)(12)(13)(14)(15), it is now known that a major fraction of the BSP which is removed from blood and excreted into bile undergoes metabolic transformation within the liver. There appears to be general agreement that the major pathway of BSP metabolism in man, rat, dog, and other species involves conjugation with the tripeptide glutathione in thioether linkage (12)(13)(14)(15).…”
mentioning
confidence: 99%
“…However, the final solution of the question must await the chemical analysis of the metabolites; this is at present under investigation. Results so far obtained (29), following the procedures outlined by Grodsky, Carbone and Fanska (8) and Combes (9), indicate the presence of the amino acids, glycine, glutamic acid, and alanine (or cysteine), in conjugates from both newborn and older children.…”
Section: Discussionmentioning
confidence: 80%
“…BSP conjugates also have been demonstrated in serum and urine (6,7). Evidence has been presented that the amino acids, glycine, glutamic acid, and cysteine, are present in the conjugates (4,8,9). The peptide, glutathione, appears to be conjugated with BSP (8,10,11).…”
mentioning
confidence: 99%