Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid

Dusza, Hanna M.; Manz, Katherine E.; Pennell, Kurt D.; Kanda, Rakesh; Legler, Juliette

doi:10.1016/j.envint.2021.106904

Cited by 16 publications

(10 citation statements)

References 90 publications

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“…Toxic substances can accumulate in wild animals and humans through bioaccumulation and biomagnification. − In some cases, top predators can accumulate exceptionally high levels of toxic substances . The application of EDA to biological samples has been employed in polar bears, seabirds, cetaceans, and humans . Simon et al identified thyroid hormone-disrupting compounds in polar bear blood plasma samples (Svalbard, Norway).…”

Section: Applications Of Eda Combined With Nts: Case Studiesmentioning

confidence: 99%

“…53 The application of EDA to biological samples has been employed in polar bears, 15 seabirds, 13 cetaceans, 56 and humans. 57 Simon et al 15 identified thyroid hormone-disrupting compounds in polar bear blood plasma samples (Svalbard, Norway). They conducted NTS with LC−TOFMS and identified branched nonylphenols and mono-and dihydroxylated-octachlorinated biphenyls as major toxicants, explaining 32% of the total measured transthyretin-binding potencies in the extracts.…”

Section: Wastewater Treatment Plant Effluentsmentioning

confidence: 99%

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Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment

Hong,

Lee,

Cha

et al. 2023

Environ. Sci. Technol.

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Effect-directed analysis (EDA) combined with nontarget screening (NTS) has established a valuable tool for the identification of unmonitored toxic substances in environmental samples. It consists of three main steps: (1) highly potent fraction identification, (2) toxicant candidate selection, and (3) major toxicant identification. Here, we discuss the methodology, current status, limitations, and future challenges of EDA combined with NTS. This method has been applied successfully to various environmental samples, such as sediments, wastewater treatment plant effluents, and biota. We present several case studies and highlight key results. EDA has undergone significant technological advancements in the past 20 years, with the establishment of its key components: target chemical analysis, bioassays, fractionation, NTS, and data processing. However, it has not been incorporated widely into environmental monitoring programs. We provide suggestions for the application of EDA combined with NTS in environmental monitoring programs and management, with the identification of further research needs.

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Section: Applications Of Eda Combined With Nts: Case Studiesmentioning

confidence: 99%

Section: Wastewater Treatment Plant Effluentsmentioning

confidence: 99%

Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment

Hong,

Lee,

Cha

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…There are hundreds of naturally-occurring and man-made compounds that have been demonstrated to be present in either amniotic fluid ( 48 – 51 ) or umbilical cord blood ( 52 ), raising the reasonable prospect that at least some of them may influence development. One prominent group of compounds has been named “endocrine-disrupting chemicals” (EDCs) which means “an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action” ( 53 ).…”

Section: Diverse Exogenous Factors Influence Pre-fertilization Embryo...mentioning

confidence: 99%

Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors

Hughes

2023

Front. Reprod. Health

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Discrete events and processes influence development of individual humans. Attribution of personhood to any individual human being cannot be disconnected from the underlying biological events and processes of early human development. Nonetheless, the philosophical, sociological and legal components that are integral to the meaning of the term as commonly used cannot be deduced from biology alone. The challenge for biomedical scientists to inform discussion in this arena then rests on profiling the key biological events and processes that must be assessed when considering how one might objectively reason about the task of superimposing the concept of personhood onto the developing biological entity of a potential human being. Endogenous genetic and epigenetic events and exogenous developmental milieu processes diversify developmental trajectories of potential individual humans prior to livebirth. First, fertilization and epigenetic resetting of each individual's organismic clock to time zero (t = 0) at the gastrulation/primitive streak stage (day 15 of embryogenesis), are two discrete unseen biological events that impact a potential individual human's attributes. Second, those two discrete unseen biological events are immersed in the continuous developmental process spanning pre-fertilization and gestation, further driving individualization of diverse attributes of each future human before the third discrete and blatant biological event of parturition and livebirth. Exposures of the gravida to multiple diverse exogenous exposures means that morphogenesis and physiogenesis of every embryo/fetus has individualized attributes for its future human lifespan. Our proposed framework based on the biological discrete events and processes spanning pre-fertilization and prenatal development, implies that personhood should be incrementally attributed, and societal protections should be graduated and applied progressively across the pre-birth timespan.

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“…As a recent example, Tian et al used EDA and examined sequential fractions of a tire rubber extract, using NTA methods, to identify a quinone transformation product that causes lethality in coho salmon ( Tian et al, 2021 ). Other examples include the use of EDA/NTA to identify estrogenic and antiandrogenic compounds in water ( Pochiraju et al, 2020 ; Muschket et al, 2018 ) and biological matrices ( Dusza et al, 2022 ).…”

Section: The Need For Quantitative Estimates Of Chemical Concentrationmentioning

confidence: 99%

Quantitative non-targeted analysis: Bridging the gap between contaminant discovery and risk characterization

McCord

Groff

Sobus

2022

Environment International

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Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid

Cited by 16 publications

References 90 publications

Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment

Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment

Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors

Quantitative non-targeted analysis: Bridging the gap between contaminant discovery and risk characterization

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