2012
DOI: 10.1016/j.ajhg.2012.09.010
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Abstract: Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.… Show more

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Cited by 80 publications
(72 citation statements)
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References 39 publications
(37 reference statements)
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“…In contrast, the function of CCDC122-LACC1 locus is yet unknown. Remarkably, our data add up to the accumulating body of evidence indicating a common association fingerprint across leprosy, Crohn's and Parkinson's disease (Orlova et al 2011): variants of leprosy susceptibility genes PARK2, TNFSF15, NOD2, LACC1, LRRK2, IL23R, IL18RAP/IL18R1 and IL12B have been described also associated with Crohn's, Parkinson's and inflammatory bowel disease (Liu et al 2012;Trabzuni et al 2013;Zhang et al 2009Zhang et al , 2011. It is possible to speculate that a better understanding of the genotype-phenotype regulatory switches controlled by these associated SNPs can help develop novel diagnostic and therapeutic approaches for infectious, inflammatory and neurodegenerative diseases.…”
Section: Discussionsupporting
confidence: 63%
“…In contrast, the function of CCDC122-LACC1 locus is yet unknown. Remarkably, our data add up to the accumulating body of evidence indicating a common association fingerprint across leprosy, Crohn's and Parkinson's disease (Orlova et al 2011): variants of leprosy susceptibility genes PARK2, TNFSF15, NOD2, LACC1, LRRK2, IL23R, IL18RAP/IL18R1 and IL12B have been described also associated with Crohn's, Parkinson's and inflammatory bowel disease (Liu et al 2012;Trabzuni et al 2013;Zhang et al 2009Zhang et al , 2011. It is possible to speculate that a better understanding of the genotype-phenotype regulatory switches controlled by these associated SNPs can help develop novel diagnostic and therapeutic approaches for infectious, inflammatory and neurodegenerative diseases.…”
Section: Discussionsupporting
confidence: 63%
“…For SNPs within previously reported loci 3,4,9,10 , we selected all of the reported genomewide and suggestive associations by choosing either the reported SNP or a proxy SNP in perfect LD (r 2 and D′ ≥ 0.99; refs. 3,4,9,10) with the reported SNP. We also selected SNPs from a number of known loci showing independent association (P value after conditional analysis on the reported association of <5 × 10 −4 ).…”
Section: Phasing and Imputationmentioning
confidence: 99%
“…The molecular nature of genetic susceptibility to leprosy has been intensively investigated by candidate gene studies 3,4 , genomewide linkage analyses [5][6][7][8] and GWAS [9][10][11] , which have identified 11 suscepti bility loci. Most of the implicated susceptibility genes encode proteins involved in immunity, whereas one locus (RAB32 at 6q24.3) suggests a role for autophagocytosis in leprosy pathogenesis.…”
mentioning
confidence: 99%
“…58 Several studies showed that rs6871626 was associated with leprosy, Crohn's disease, Takayasu arteritis, and ulcerative colitis. [58][59][60] The current study showed that rs6871626 was associated with VKH disease but not with AS. Our study is in agreement with a previous study that showed that rs6871626 was not associated with the susceptibility to AS in mainland Han Chinese.…”
Section: Discussionmentioning
confidence: 99%