Identification of<i>Streptococcus suis</i>Meningitis through Population-Based Surveillance, Togo, 2010–2014

Tall, Haoua; Njanpop-Lafourcade, Berthe-Marie; Mounkoro, Didier; Tidjani, Loukoumane; Agbenoko, Kodjo; Alassani, Issifou; Amidou, Moussa; Tamekloe, Stanislas; Laing, Ken; Witney, Adam A.; Hinds, Jason; Linden, Mark van der; Gessner, Bradford D.; Moïsi, Jennifer C

doi:10.3201/eid2207.151511

Cited by 10 publications

(23 citation statements)

References 8 publications

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“…This is the second report of a human S. suis meningitis in Togo, which, together with a recently published limited case-series [7], highlights the emergence of this zoonotic pathogen in Africa. Nevertheless, swine industry and pork products consumption, although extremely low compared to other continents, are steadily increasing [8], which might lead to a significant rise of S. suis infections in the future.…”

Section: Discussionmentioning

confidence: 67%

“…Nevertheless, swine industry and pork products consumption, although extremely low compared to other continents, are steadily increasing [8], which might lead to a significant rise of S. suis infections in the future. Besides, S. suis infections are not limited to adult cases but also affect children [7], and specific attention should be paid to this other potential high-risk group. This case-report, for which clinical data, microbiological findings, and outcome were similar to those reported elsewhere [1, 2], emphasizes the need for educating both clinicians and exposed groups about S. suis infections and their severity in non-endemic countries.…”

Section: Discussionmentioning

confidence: 99%

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Human meningitis due to Streptococcus suis in Lomé, Togo: a case report

et al. 2016

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Background Streptococcus suis is a zoonotic pathogen which represents the leading cause of meningitis in Southeast Asia and an emerging pathogen in the Western world, the main risk factor for infection being contact with pigs. In Africa, the prevalence of S. suis infections in swine and humans is largely unrecognized, with only one recent report of a limited case series.Case presentationWe describe a human case of meningitis due to S. suis in a 32-year-old man living in Togo. The patient had no particular medical history and no risk factors for immunodeficiency but reported regular contact with pork products. Using specific immunological and molecular methods, we characterized the isolate as S. suis serotype 2, ST1, one the most prevalent and virulent clone worldwide. The outcome was favorable after one week of adapted antibiotic therapy but the patient was left with severe hearing disorders.ConclusionsThis work highlights the emergence of this pathogen in Africa and reinforces the need for accurate epidemiological and surveillance studies of S. suis infections and for educating clinicians and exposed groups in non-endemic countries.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Human meningitis due to Streptococcus suis in Lomé, Togo: a case report

et al. 2016

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“…Included studies with different study designs were conducted in 9 distinctive countries. Among these, there were 1 randomized double-blind, placebo-controlled trial 10 , 3 case-control studies in which there were 1 matched case-control 37 , 1 retrospective case-control 38 and 1 prospective case-control studies 19 , 28 descriptive studies including 3 public health surveillance studies 27 , 40 , 41 , 2 outbreak investigations 36 , 39 and 1 epidemiological analysis in China 23 , a population-based study on a food safety campaign 30 and a retrospective cohort identifying risk factor for S . suis mortality 34 , 3 retrospective reviews 16 , 20 , 21 and 17 case reports or case series 9 , 11 , 13 – 15 , 17 , 18 , 22 , 24 – 26 , 28 , 29 , 31 – 33 , 35 .…”

Section: Resultsmentioning

confidence: 99%

“…Majorities of studies were from Asia mainly Thailand, China, Hong Kong and Vietnam. Fourteen studies were from Thailand 16 , 18 , 20 , 21 , 26 – 31 , 33 , 34 , 39 , 40 , four each were from China 23 , 24 , 36 , 37 , Hong Kong 11 , 15 , 22 , 25 and Vietnam 10 , 19 , 35 , 38 , two studies were from the Netherlands 9 , 13 , and one study each from Japan 14 , Serbia 17 , the UK 32 and Togo 41 . Two out of the four articles from China were from epidemiological investigation in Sichuan outbreak in 2005 36 , 37 .…”

Section: Resultsmentioning

confidence: 99%

Risk factors for Streptococcus suis infection: A systematic review and meta-analysis

Rayanakorn

Goh

Lee

et al. 2018

Sci Rep

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Streptococcus suis (S. suis) is a gram-positive bacterial pathogen in pigs which can cause serious infections in human including meningitis, and septicaemia resulting in serious complications. There were discrepancies between different data and little is known concerning associated risk factors of S. suis. A systematic review and meta-analysis was conducted to investigate on S. suis infection risk factors in human. We searched eight relevant databases using the MeSH terms “Streptococcus suis” OR “Streptococcus suis AND infection” limited in human with no time nor language restriction. Out of 4,999 articles identified, 32 and 3 studies were included for systematic review and meta-analysis respectively with a total of 1,454 Streptococcus suis cases reported. S. suis patients were generally adult males and the elderly. The mean age ranged between 37 to 63 years. Meningitis was the most common clinical manifestation, and deafness was the most common sequelae found among survivors followed by vestibular dysfunction. Infective endocarditis was also noted as among the most common clinical presentations associated with high mortality rate in a few studies. Meta-analyses categorized by type of control groups (community control, and non-S. suis sepsis) were done among 850 participants in 3 studies. The combined odd ratios for studies using community control groups and non-S. Suis sepsis as controls respectively were 4.63 (95% CI 2.94–7.29) and 78.00 (95% CI 10.38–585.87) for raw pork consumption, 4.01 (95% CI 2.61–6.15) and 3.03 (95% CI 1.61–5.68) for exposure to pigs or pork, 11.47, (95% CI 5.68–23.14) and 3.07 (95% CI 1.81–5.18) for pig-related occupation and 3.56 (95% CI 2.18–5.80) and 5.84 (95% CI 2.76–12.36) for male sex. The results were found to be significantly associated with S. suis infection and there was non-significant heterogeneity. History of skin injury and underlying diseases were noted only a small percentage in most studies. Setting up an effective screening protocol and public health interventions would be effective to enhance understanding about the disease.

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“…Streptococcus suis infection has nonspecific clinical symptoms in the early stages and progresses rapidly. Mortality rates (0-33.3%) are low compared with meningitis caused by other pathogens (5)(6)(7)(8)(9)(10)(11)(12). However, toxic shock-like syndrome caused by this pathogen has a high mortality rate in China (62 and 50%) and Thailand (80%) (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Culture-Negative Streptococcus suis Infection Diagnosed by Metagenomic Next-Generation Sequencing

Dai

Chen

Chang

et al. 2019

Front. Public Health

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Background: Streptococcus suis is a zoonotic pathogen that can cause severe infections such as meningitis and septicemia in both swine and humans. Rapid and accurate identification of the causative agent is very important for guiding clinical choices in administering countermeasures. Case Report: Here, we report a case of fatal S. suis infection in a patient who worked as a butcher in China. The 59-year-old man, who had previously undergone splenectomy, injured his finger while processing pork and developed severe sepsis. While blood cultures were negative following antibiotic treatment, S. suis was determined to be the causative agent by metagenomic next-generation sequencing (mNGS) and Sanger sequencing. Conclusion: Identification of etiological agents using techniques such as blood culture prior to antibiotic treatment is very important. mNGS may represent a useful method for diagnosis of infectious diseases, especially post-antibiotic treatment.

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Identification ofStreptococcus suisMeningitis through Population-Based Surveillance, Togo, 2010–2014

Cited by 10 publications

References 8 publications

Human meningitis due to Streptococcus suis in Lomé, Togo: a case report

Human meningitis due to Streptococcus suis in Lomé, Togo: a case report

Risk factors for Streptococcus suis infection: A systematic review and meta-analysis

Culture-Negative Streptococcus suis Infection Diagnosed by Metagenomic Next-Generation Sequencing

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