Identification of human papillomavirus type 53 L1, E6 and E7 variants in isolates from Brazilian women

Oliveira, Ledy H. S.; Santos, Larissa Silva; Augusto, Everton Faccini; Neves, Felipe Piedade Gonçalves

doi:10.1016/j.meegid.2011.10.018

Cited by 3 publications

(3 citation statements)

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“…The oncogenic E6 and E7 proteins are commonly mutated, whereas synonymous and nonsynonymous mutations are also reported in the L1 gene in HPV 16 [25][26][27]. Several studies investigated the genetic variability of L1, E6, and E7 genes in HPV 18, 38, 52, and 53 and showed that the intratypic variants were frequently found [28][29][30][31]. Some of these mutations increased the oncogenic potential and the infection efficiency of the viruses.…”

Section: Resultsmentioning

confidence: 99%

“…Persistent infection with high-risk Alpha PVs is a prerequisite for the development of cervical cancer and its histological precursor, cervical intraepithelial lesions. Twelve HPVs (16,18,31,33,35,39,45, 51, 52, 56, 58, and 59) are classified by the International Agency for Research on Cancer as being carcinogenic to humans, with HPV 68 being recognized as probably carcinogenic. Several other HPV types (26,30,34,53,66,67,69,70,73,82,85, and 97) are possibly carcinogenic based on evolutionary similarity to the known cancer-causing types [3].…”

Section: Introductionmentioning

confidence: 99%

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HPV Prevalence and Detection of Rare HPV Genotypes in Hong Kong Women from Southern China with Cytological Abnormalities

Chu

Chow

et al. 2013

ISRN Virology

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Human papillomavirus (HPV) has been identified as the primary cause of cervical squamous intraepithelial lesion and invasive cervical cancer. The emergence of various commercial HPV genotyping kits with different characteristics facilitates the detection of most high-risk and low-risk HPV genotypes, but the rare HPV types are usually underdiagnosed. In the present study, HPV detection was performed using the GenoFlow HPV Array Test kit (DiagCor Bioscience), which can identify 33 HPV subtypes by specific probes. Besides, a HPV consensus probe (universal probe) was designed to capture not only the 33 genotypes but also rare subtypes. Of the 1643 Southern Chinese women tested between 2012 and 2013, the HPV prevalence was 42.3%, with HPV 52 (139/1643, 8.5%), HPV 81 (89/1643, 5.4%), and HPV 16 (63/1643, 3.8%) being the most frequent subtypes detected. Among all 695 HPV-positive cases, 56 (8.1%) cases were only detected by the universal probe, in which 5 were either ASCUS or LSIL cases. Sequencing results confirmed HPV types 30, 91, and 74, and the intratypic variants of HPV 72 and 82 were present in the 5 cases. The result suggests that some rare HPV subtypes might be involved in cervical lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HPV Prevalence and Detection of Rare HPV Genotypes in Hong Kong Women from Southern China with Cytological Abnormalities

Chu

Chow

et al. 2013

ISRN Virology

View full text Add to dashboard Cite

show abstract

“…estimated potential for progression to malignancy and are both highly genetically diverse with distinct intratype variants [6][7][8][9]. There is currently no evidence that L1 polymorphisms are associated with cervical malignancy but the diversity of these types and their worldwide distribution are striking [10][11][12][13]. While the detection of HPV66 is currently included in the majority of commercially available tests for cervical cancer screening, convincing data on the clinical significance and malignant potential of HPV53 are lacking [14,15].…”

mentioning

confidence: 99%