Identification of five novel <scp>MHC</scp> class <scp>II</scp> alleles in cynomolgus macaques of Vietnamese origin

Wang, W.; Lu, Yueer; Zhuo, Min; Ling, Fei

doi:10.1111/tan.12840

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparative study of DRB exon 2 in various Mafa populations confirmed that Mauritius and the Philippines have a restricted DRB polymorphism when compared to Vietnamese or Indonesian macaques [45]. The Vietnamese and Indonesian populations have a high diversity of DRB alleles [66,67]. Extensive interspecies DRB allele sharing was demonstrated by comparison with Macaca mulatta and Macaca nemestrina [49,68].…”

Section: Diversity Of Cynomolgus Macaque Populationsmentioning

confidence: 99%

The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine

Shiina

Blancher

2019

Cells

View full text Add to dashboard Cite

Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated.

show abstract