Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride

Evaluation of Dopamine D-2 Receptor Occupancy by Clozapine, Risperidone, and Haloperidol In Vivo in the Rodent and Nonhuman Primate Brain Using 18F-Fallypride

“…The DV for thalamus was approximately 10% of that found in the caudate putamen and the cortex, temporal, and frontal, were about 5% of that found in the caudate. These findings are consistent with the dopamine receptor concentrations located extrastriatally with respect to that found in the striata (Hall et al 1994;Kessler et al 1993).…”

Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons

“…D 2 receptor sites in these regions were previously identified using membrane binding and autoradiography (Janowski et al 1992;Kessler et al 1993), and D 2 mRNA has been identified in the nonhuman primate (Choi et al 1995). A recent report demonstrated the presence of D3 receptor mRNA in the human thalamus (Suzuki et al 1998).…”

Decreased Hippocampal 5-HT2A Receptor Binding in Older Depressed Patients Using [18F]Altanserin Positron Emission Tomography

“…Given the 20-fold difference in affinity and the presence of only equal numbers of 5-HT 2C receptors, there should be only a small percentage of the [ 18 F]altanserin uptake being associated with the 5-HT 2C receptor. In the case of dopamine-2 receptors, there is both an extremely low concentration in hippocampus (Kesser et al, 1993) as well as a low affinity (K i ¼ 62 nM; Lemaire et al, 1991) essentially removing the possibility of significant binding to this receptor.…”