2020
DOI: 10.3390/biomedicines8070181
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Abstract: As a part of an abnormal healing process of dermal injuries and irritation, keloid scars arise on the skin as benign fibroproliferative tumors. Although the etiology of keloid scarring remains unsettled, considerable recent evidence suggested that keloidogenesis may be driven by epigenetic changes, particularly, DNA methylation. Therefore, genome-wide scanning of methylated cytosine-phosphoguanine (CpG) sites in extracted DNA from 12 keloid scar fibroblasts (KF) and 12 control skin fibroblasts (CF) (si… Show more

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Cited by 13 publications
(12 citation statements)
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References 108 publications
(112 reference statements)
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“…21 Each of these is essential in normal tissue processes, including skin homeostasis and wound healing, and alterations and aberrations in these processes are implicated in pathological fibrotic conditions, including keloid scars. [22][23][24][25] Here, we will review the current research on the role of these in keloid scarring.…”
Section: Epi G Ene Ti C Reg Ul Ati On Of G Ene E Xpre Ss I Onmentioning
confidence: 99%
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“…21 Each of these is essential in normal tissue processes, including skin homeostasis and wound healing, and alterations and aberrations in these processes are implicated in pathological fibrotic conditions, including keloid scars. [22][23][24][25] Here, we will review the current research on the role of these in keloid scarring.…”
Section: Epi G Ene Ti C Reg Ul Ati On Of G Ene E Xpre Ss I Onmentioning
confidence: 99%
“…Of these, 20,695 CpG sites were hypomethylated and 79,305 CpG sites were hypermethylated, and the differentially methylated genes had roles in cancer progression and fibrosis. 22 Patient concordance for these studies was not ideal-apart from age, sex, body site, ethnicity, time since injury and many other factors were either different or not stated between studies, and this heterogeneity may be obscuring true results. To date, all studies in cultured cells have been on keloid fibroblasts-methylation patterns in other major cell types like keratinocytes have not been characterised.…”
Section: Dna Me Thyl Ati On In Keloidsmentioning
confidence: 99%
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“…Based on genomewide scanning of methylated cytosine-phosphoguanine (CpG) sites in keloids, a total of 100,000 differentially methylated CpG sites were identified, of which 20,695 were hypomethylated and 79,305 were hypermethylated. The most functionally enriched methylated genes were strongly involved in the regulation of transcription, DNA-templated, and histone exchange, which shed light on the underlying mechanism of keloid formation and remission [16]. By employing genome-wide differentially methylated gene profiles, Jones et al recognized 152 significant differentially methylated genes in keloid [17].…”
Section: Dna Methylation Expression Profiles In Keloidmentioning
confidence: 99%